San Luis vs. Santos Laguna prediction, odds, Liga MX picks [4/22/2026]

Atletico San Luis and Santos Laguna will meet in the Liga MX playoffs at Estadio Alfonso Lastras on Wednesday, with kickoff at 9:00 PM ET.

Based on updated simulation results, Dimers' advanced Liga MX model predicts San Luis as the most likely winner of the Atletico San Luis vs. Santos Laguna game.

This article offers a closer look at Wednesday's match, including best bets and picks.

Atletico San Luis vs. Santos Laguna prediction: Who will win?

Using innovative machine learning and data analysis, we have simulated the outcome of Wednesday's Liga MX game between Atletico San Luis and Santos Laguna, forming part of our Liga MX predictions coverage.

Our independent predictive model currently indicates a 57.9% chance of Atletico San Luis winning, a 20.7% chance for Santos Laguna, and a 21.4% chance of a draw.

Atletico San Luis vs. Santos Laguna odds

We have sourced the best Liga MX odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Atletico San Luis vs. Santos Laguna picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

According to our Liga MX best bets, the top play to make on this game is San Luis to win.

These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.

Atletico San Luis vs. Santos Laguna: Correct score and BTTS predictions

Here are the top three most likely final scores according to our model, with a 1-1 draw being the most probable:

When it comes to the both teams to score (BTTS) market, we project a 58.2% chance of both Atletico San Luis and Santos Laguna finding the net and a 41.8% chance that at least one doesn’t.

These predictions are based on each team's average score according to our machine learning model, which means the most likely correct score can differ from our predicted winner.

San Luis vs. Santos Laguna game-day updates and essential details

Wednesday's action between Atletico San Luis and Santos Laguna at Estadio Alfonso Lastras is scheduled to start at 9:00 PM ET.

• Who: Atletico San Luis vs. Santos Laguna
• Date: Wednesday, April 22, 2026
• Time: 9:00 PM ET/6:00PM PT
• Venue: Estadio Alfonso Lastras

Conclusion

According to our computer model, Atletico San Luis has a 57.9% win probability on Wednesday, Santos Laguna has a 20.7% win probability, and there is a 21.4% chance that the game will end in a draw.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.