Santos Laguna vs. Puebla prediction, odds, Liga MX picks [3/22/2026]

Santos Laguna and Puebla are scheduled to meet in the Liga MX playoffs at Estadio Corona on Sunday, starting at 7:00 PM ET.

Based on updated simulation results, Dimers' advanced Liga MX model predicts Puebla as the most likely winner of the Santos Laguna vs. Puebla game.

This article offers further insights into Sunday's matchup, including best bets and picks.

Santos Laguna vs. Puebla prediction: Who will win?

Using innovative machine learning and data, we have simulated the outcome of Sunday's Liga MX matchup between Santos Laguna and Puebla 10,000 times as part of our Liga MX predictions coverage.

Our famous predictive model currently suggests a 37.0% chance of Santos Laguna winning, a 37.7% chance for Puebla, and a 25.3% chance of a draw.

Additionally, the over/under total of 2.5 goals has a 53% chance of going over, according to our model.

Santos Laguna vs. Puebla odds

We have researched the best Liga MX odds in America for this game, which are listed here:

Moneyline

Total Goals

All odds are correct at the time of publication and are subject to change.

Santos Laguna vs. Puebla picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

According to our Liga MX best bets, the top play to make on this game is Puebla to win.

These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.

Santos Laguna vs. Puebla: Correct score and BTTS predictions

Here are the top three most likely final scores according to our model, with a 1-1 draw being the most probable:

When it comes to the both teams to score (BTTS) market, we project a 56.9% chance of both sides finding the net and a 43.1% chance that at least one doesn’t.

These predictions are based on each team's average score according to our machine learning model, meaning the most likely correct score may differ from our predicted winner.

Santos Laguna vs. Puebla game-day updates and essential details

Sunday's action between Santos Laguna and Puebla at Estadio Corona is scheduled to commence at 7:00 PM ET.

• Who: Santos Laguna vs. Puebla
• Date: Sunday, March 22, 2026
• Time: 7:00 PM ET/4:00PM PT
• Venue: Estadio Corona

Conclusion

According to our computer model, Santos Laguna has a 37.0% win probability on Sunday, Puebla has a 37.7% win probability, and there is a 25.3% chance that the game will end in a draw.

AI and automation have enhanced this article to quickly deliver accurate Santos Laguna vs. Puebla insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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