Pumas UNAM vs. San Luis prediction, odds, Liga MX picks [10/22/2025]

Pumas UNAM and Atletico San Luis are scheduled to meet in Liga MX on Wednesday, with kickoff at 11:05PM ET.

Based on the latest simulation results, Dimers' advanced Liga MX model projects Pumas UNAM as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's Pumas UNAM-San Luis game 10,000 times," said Dave Garofolo from Dimers.

"Taking into account the most current updates and numerous additional factors, our prediction gives Pumas UNAM a 55.5% chance of winning, Atletico San Luis a 21.1% chance, and a 23.4% chance of a draw."

For expanded analysis of Wednesday's matchup, including best bets and picks, visit our interactive Pumas UNAM vs. Atletico San Luis predictions page.

Pumas UNAM vs. Atletico San Luis prediction: Who will win?

Using trusted machine learning and statistical analysis, we have simulated the result of Wednesday's Liga MX game between Pumas UNAM and Atletico San Luis 10,000 times as part of our Liga MX predictions coverage.

Our leading predictive model indicates a 55.5% chance of Pumas UNAM winning, a 21.1% chance for Atletico San Luis, and a 23.4% chance of a draw.

Additionally, the over/under total of 2.5 goals has a 52% chance of going over, according to our model.

Pumas UNAM vs. Atletico San Luis odds

We have researched the best Liga MX odds in America for this game, which are listed here:

Moneyline

Pumas UNAM	Atletico San Luis	Draw
-110	+310	+255

Total Goals

Over 2.5	Under 2.5
-112	-108

All odds are correct at the time of publication and are subject to change.

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Pumas UNAM vs. Atletico San Luis picks and best bets

Our model's biggest edge in today's Pumas UNAM vs. Atletico San Luis matchup is on the moneyline.

Our expert predictions, matched against the latest odds, reveal the best Liga MX picks and Liga MX best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Pumas UNAM vs. Atletico San Luis: Correct score and BTTS predictions

Here are the top three most likely final scoresaccording to our model, with a 1-0 Pumas UNAM win being the most probable:

Final Score	Probability
PUM 1-0 ASL	11.2%
PUM 1-1 ASL	11.1%
PUM 2-0 ASL	9.9%

When it comes to the both teams to score (BTTS) market, we project a 52.1% chance that both Pumas UNAM and Atletico San Luis score, and a 47.9% probability of at least one team being held goalless.

These predictions are based on each team's average score after 10,000 simulations.

Pumas UNAM vs. San Luis game-day updates and essential details

Wednesday's action between Pumas UNAM and Atletico San Luis is scheduled to start at 11:05PM ET.

• Who: Pumas UNAM vs. Atletico San Luis
• Date: Wednesday, October 22, 2025
• Time: 11:05PM ET/8:05PM PT

Dimers' in-depth preview of Wednesday's Pumas UNAM vs. Atletico San Luis matchup includes our prediction, picks and the latest betting odds.

Before making any San Luis vs. Pumas UNAM picks, be sure to check out the latest Liga MX predictions and betting advice from Dimers Pro.

Conclusion

According to our computer model, Pumas UNAM has a 55.5% win probability on Wednesday, Atletico San Luis has a 21.1% win probability, and there is a 23.4% chance that the game will end in a draw.

AI and automation have enhanced this article to quickly deliver accurate Pumas UNAM vs. Atletico San Luis insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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