Mazatlan vs. Santos Laguna prediction, odds, Liga MX picks [10/21/2025]

Mazatlan and Santos Laguna will lock horns in Liga MX on Tuesday, starting at 11:00PM ET.

Based on the latest simulations, Dimers' advanced Liga MX model predicts Mazatlan as the most likely winner of today's game.

For expanded analysis of Tuesday's matchup, including best bets and picks, visit our interactive Mazatlan vs. Santos Laguna predictions page.

Mazatlan vs. Santos Laguna prediction: Who will win?

Using trusted machine learning and statistical analysis, we have simulated the result of Tuesday's Liga MX matchup between Mazatlan and Santos Laguna 10,000 times as part of our Liga MX predictions coverage.

Our independent predictive model suggests a 51.0% chance of Mazatlan winning, a 23.5% chance for Santos Laguna, and a 25.5% chance of a draw.

Additionally, the 2.5-goal over/under has a 54% chance of staying under, according to our model.

Mazatlan vs. Santos Laguna odds

We have sourced the best Liga MX odds in America for this game, which are listed here:

Moneyline

Mazatlan	Santos Laguna	Draw
+115	+220	+260

Total Goals

Over 2.5	Under 2.5
-148	+120

All odds are correct at the time of publication and are subject to change.

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Mazatlan vs. Santos Laguna picks and best bets

Our model's strongest edge in today's Mazatlan vs. Santos Laguna matchup is on the total.

Our expert predictions, aligned with the best odds, reveal the best Liga MX picks and Liga MX best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Mazatlan vs. Santos Laguna: Correct score and BTTS predictions

The top three most likely final scores, according to our model, are listed below, with a 1-0 Mazatlan win being the most probable:

Final Score	Probability
MZA 1-0 SLA	12.5%
MZA 1-1 SLA	12.1%
MZA 2-0 SLA	9.7%

When it comes to the both teams to score (BTTS) market, we project a 48.9% chance that both teams scoring, and a 51.1% probability of at least one team being held goalless.

These predictions are based on each team's average score after 10,000 simulations.

Mazatlan vs. Santos Laguna game-day updates and essential details

Tuesday's action between Mazatlan and Santos Laguna is scheduled to commence at 11:00PM ET.

• Who: Mazatlan vs. Santos Laguna
• Date: Tuesday, October 21, 2025
• Time: 11:00PM ET/8:00PM PT

Dimers' comprehensive preview of Tuesday's Mazatlan vs. Santos Laguna matchup includes our prediction, picks and the latest betting odds.

Before making any Santos Laguna vs. Mazatlan picks, be sure to check out the latest Liga MX predictions and betting advice from Dimers Pro.

Conclusion

According to our computer model, Mazatlan has a 51.0% win probability on Tuesday, Santos Laguna has a 23.5% win probability, and there is a 25.5% chance that the game will end in a draw.

AI and automation have enhanced this article to quickly deliver accurate Mazatlan vs. Santos Laguna insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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More on Liga MX

Keep up with the latest Liga MX news and parlay picks throughout the season.

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