Club America vs. Puebla prediction, odds, Liga MX picks [10/21/2025]

Club America and Puebla will meet in Liga MX at Estadio Ciudad de los Deportes on Tuesday, starting at 9:00PM ET.

Based on the latest simulation results, Dimers' advanced Liga MX model predicts Club America as the most likely winner of today's game.

For further insights into Tuesday's matchup, including best bets and picks, visit our interactive Club America vs. Puebla predictions page.

Club America vs. Puebla prediction: Who will win?

Using trusted machine learning and data, we have simulated the outcome of Tuesday's Liga MX game between Club America and Puebla 10,000 times as part of our Liga MX predictions coverage.

Our leading predictive model indicates a 76.4% chance of Club America winning, an 8.6% chance for Puebla, and a 15.0% chance of a draw.

Club America vs. Puebla odds

We have sourced the best Liga MX odds in America for this game, which are listed here:

Market	Club America	Puebla	Draw
Moneyline	-450	+1100	+500

All odds are correct at the time of publication and are subject to change.

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Club America vs. Puebla picks and best bets

Our model's strongest edge in today's Club America vs. Puebla matchup is on the moneyline.

Our expert predictions, aligned with the current odds, reveal the best Liga MX picks and Liga MX best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Club America vs. Puebla: Correct score and BTTS predictions

The top three most likely final scores, according to our model, are listed below, with a 2-0 Club America win being the most probable:

Final Score	Probability
AME 2-0 PUE	12.2%
AME 3-0 PUE	10.3%
AME 1-0 PUE	9.7%

When it comes to the both teams to score (BTTS) market, we project a 47.8% chance that both Club America and Puebla score, and a 52.2% probability of at least one team being held goalless.

These predictions are based on each team's average score after 10,000 simulations.

Club America vs. Puebla game-day updates and essential details

Tuesday's action between Club America and Puebla at Estadio Ciudad de los Deportes is scheduled to commence at 9:00PM ET.

• Who: Club America vs. Puebla
• Date: Tuesday, October 21, 2025
• Time: 9:00PM ET/6:00PM PT
• Venue: Estadio Ciudad de los Deportes

Dimers' in-depth preview of Tuesday's Club America vs. Puebla matchup includes our prediction, picks and the latest betting odds.

Before making any Puebla vs. Club America picks, be sure to check out the latest Liga MX predictions and betting advice from Dimers Pro.

Conclusion

According to our computer model, Club America has a 76.4% win probability on Tuesday, Puebla has an 8.6% win probability, and there is a 15.0% chance that the game will end in a draw.

AI and automation have enhanced this article to quickly deliver accurate Club America vs. Puebla insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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More on Liga MX

Keep up with the latest Liga MX news and parlay picks throughout the season.

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