May 28, 2026
Twins vs. White Sox prediction: Why White Sox are favored to win Thursday's MLB matchup [5/28/2026]
Read Article Cubs vs. Pirates prediction: Why Pittsburgh is favored to win Thursday's MLB matchup [5/28/2026]
Updated: | First published:
Written by Dave Garofolo, Content Producer
Get Chicago Cubs vs Pittsburgh Pirates predictions for MLB Thursday.
The Pittsburgh Pirates and Chicago Cubs are scheduled to meet in MLB action at PNC Park on Thursday, starting at 6:40 PM ET.
The Pirates will send Paul Skenes (6-4, 3.00 ERA) to the mound, pitting him against Colin Rea (4-3, 4.83 ERA) for the Cubs.
Based on updated simulations, Dimers' advanced MLB model projects the Pirates as the most likely winner of the Cubs vs. Pirates game.
This article offers a closer look at Thursday's matchup, including best bets and picks.
Cubs vs. Pirates prediction: Who will win and cover?
Using trusted machine learning and data, we have simulated the outcome of Thursday's MLB matchup between the Cubs and Pirates, forming part of our MLB predictions coverage.
Our independent predictive model currently gives the Pirates a 59% chance of defeating the Cubs.
According to our model, the Cubs (+1.5) have a 59% chance of covering the run line, while the over/under total of 7.5 runs has a 51% chance of going over.
Cubs vs. Pirates odds [5/28/2026]
We have researched the best MLB odds in America for this game, which are listed here:
| Bet Type | Cubs | Pirates |
|---|---|---|
| Run Line | +1.5 (-146) | -1.5 (+128) |
| Moneyline | +146 | -174 |
| Total | o7.5 (-105) | u7.5 (-110) |
All odds are correct at the time of publication and are subject to change.
Cubs vs. Pirates picks and best bet
After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Run Line | Cubs +1.5 | -146 |
| Moneyline | Cubs | +146 |
| Total | Over 7.5 | -105 |
According to our MLB best bets, the top play to make on this game is Cubs to win.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Cubs vs. Pirates game-day updates and essential details
Thursday's MLB game between the Pirates and Cubs at PNC Park is scheduled to commence at 6:40 PM ET.
- Who: Chicago Cubs vs. Pittsburgh Pirates
- Date: Thursday, May 28, 2026
- Time: 6:40 PM ET/3:40PM PT
- Venue: PNC Park
Conclusion
We predict the Pirates, with a 59% win probability, will likely beat the Cubs in Thursday's MLB matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
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Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
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