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Read Article MLB picks today: Wednesday's MLB best bets include Guardians vs. Tigers play [5/20/2026]
Updated: | First published:
Written by Jason Bevilacqua, Head of Content and Communities
Get MLB picks today and best bets for Wednesday, May 20, 2026.
Today’s MLB picks for May 20, 2026 are here, with Guardians vs. Tigers and Pirates vs. Cardinals among the top plays identified by our model across Wednesday’s MLB schedule.
Dimers’ predictive analytics engine runs 24/7, going over the latest baseball odds to uncover top betting edges. The result? Data-backed picks that help Dimers Pro members make smarter decisions.
List of MLB best bets tonight [5/20, updated 8:32PM ET]
Below, you’ll find today’s best baseball bets, ranked by edge for Wednesday, May 20, 2026.
Guardians vs. Tigers over 7.5 runs (+108)
- Edge: 4.5%
- Probability: 52.5%
- Matchup: Guardians vs. Tigers (1:10PM ET, Thursday)
Our model has identified value on over 7.5 runs in Guardians vs. Tigers at +108 odds. A 52.5% probability produces an edge of 4.5%, making this the strongest play for today's MLB slate.
Pirates vs. Cardinals over 7.5 runs (-108)
- Edge: 4.2%
- Probability: 56.2%
- Matchup: Pirates vs. Cardinals (1:15PM ET, Thursday)
Pirates vs. Cardinals over 7.5 runs carries a 4.2% edge and a probability of 56.2% at -108 odds, according to our model.
Athletics vs. Angels over 9.5 runs (-102)
- Edge: 3.4%
- Probability: 53.9%
- Matchup: Athletics vs. Angels (9:38PM ET, Wednesday)
Athletics vs. Angels over 9.5 runs at -102 odds shows a 3.4% edge, supported by a 53.9% probability in simulations.
Braves vs. Marlins over 7.5 runs (-108)
- Edge: 2.7%
- Probability: 54.7%
- Matchup: Braves vs. Marlins (6:40PM ET, Thursday)
A 2.7% edge and 54.7% probability make Braves vs. Marlins over 7.5 runs at a value play in the Braves vs. Marlins matchup, per our model.
MLB best bets summary: Wednesday, 5/20/2026
As of 8:32PM ET, here are our top MLB bets by edge recommended by our model:
| Matchup | Bet | Odds | Edge | Probability |
|---|---|---|---|---|
| Guardians vs. Tigers | Over 7.5 Runs | +108 @ Polymarket | 4.5% | 52.5% |
| Pirates vs. Cardinals | Over 7.5 Runs | -108 @ Polymarket | 4.2% | 56.2% |
| Athletics vs. Angels | Over 9.5 Runs | -102 @ Polymarket | 3.4% | 53.9% |
| Braves vs. Marlins | Over 7.5 Runs | -108 @ Kalshi | 2.7% | 54.7% |
List of upcoming MLB games to bet on [5/20/2026]
- Dodgers vs. Padres (8:40PM ET, Wednesday)
- Athletics vs. Angels (9:38PM ET, Wednesday)
- Guardians vs. Tigers (1:10PM ET, Thursday)
- Pirates vs. Cardinals (1:15PM ET, Thursday)
- Braves vs. Marlins (6:40PM ET, Thursday)
Conclusion
Our MLB best bets are locked and loaded for May 20, 2026, featuring plays such as over 7.5 runs in the Guardians vs. Tigers matchup and over 7.5 runs in the Pirates vs. Cardinals matchup. Powered by advanced simulations, these picks are here to boost your betting game.
Our predictions are rooted in current data to help you make informed decisions. For additional resources and advice, head to our Responsible Gambling hub.
All odds and probabilities in this article are correct and accurate at the time of publication.
Jason Bevilacqua, an expert in MLB, NHL, NBA, MLS, and NFL, delivers game previews, best bets, and props. Since 2020, as Head of Social and Community at Dimers, he has contributed insightful articles utilizing data-driven models and simulations.
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