MLB picks today: Wednesday's MLB best bets include Brewers vs. Cubs play [5/20/2026]

Brewers vs. Cubs over 6.5 runs (+106)

• Edge: 8.5%
• Probability: 57%
• Matchup: Brewers vs. Cubs (7:40PM ET, Wednesday)

Our model has identified value on over 6.5 runs in Brewers vs. Cubs at +106 odds. A 57% probability produces an edge of 8.5%, making this the strongest play for today's MLB slate.

Dodgers vs. Padres over 7.5 runs (+108)

• Edge: 6.5%
• Probability: 54.5%
• Matchup: Dodgers vs. Padres (8:40PM ET, Wednesday)

Dodgers vs. Padres over 7.5 runs carries a 6.5% edge and a probability of 54.5% at +108 odds, according to our model.

Astros vs. Twins over 7.5 runs (-115)

• Edge: 6.2%
• Probability: 59.7%
• Matchup: Astros vs. Twins (1:40PM ET, Wednesday)

Astros vs. Twins over 7.5 runs at -115 odds shows a 6.2% edge, supported by a 59.7% probability in simulations.

Rangers vs. Rockies over 10.5 runs (+102)

• Edge: 5.9%
• Probability: 55.4%
• Matchup: Rangers vs. Rockies (3:10PM ET, Wednesday)

A 5.9% edge and 55.4% probability make Rangers vs. Rockies over 10.5 runs at a value play in the Rangers vs. Rockies matchup, per our model.

Red Sox vs. Royals over 7.5 runs (-115)

• Edge: 5.7%
• Probability: 59.2%
• Matchup: Red Sox vs. Royals (7:40PM ET, Wednesday)

Red Sox vs. Royals over 7.5 runs at -115 odds presents a 5.7% edge, with simulations resulting in a probability of 59.2%.

Giants vs. Diamondbacks over 8.5 runs (-115)

• Edge: 5.0%
• Probability: 58.5%
• Matchup: Giants vs. Diamondbacks (3:40PM ET, Wednesday)

Our model finds value on over 8.5 runs in Giants vs. Diamondbacks at -115 odds, supported by an edge of 5.0%.

Blue Jays vs. Yankees over 7.5 runs (-117)

• Edge: 5.0%
• Probability: 59%
• Matchup: Blue Jays vs. Yankees (7:05PM ET, Wednesday)

Our model has uncovered value on Blue Jays vs. Yankees over 7.5 runs at -117 odds. A 59% probability produces a 5.0% edge, making this a strong play for today's MLB action.

Pirates vs. Cardinals over 7.5 runs (-111)

• Edge: 4.3%
• Probability: 56.8%
• Matchup: Pirates vs. Cardinals (7:45PM ET, Wednesday)

A 4.3% edge on a 56.8% probability makes over 7.5 runs at -111 odds a solid value play in today's Pirates vs. Cardinals matchup.

White Sox vs. Mariners over 7.5 runs (+104)

• Edge: 4.2%
• Probability: 53.2%
• Matchup: White Sox vs. Mariners (4:10PM ET, Wednesday)

Our model projects value on over 7.5 runs at +104 odds. A 53.2% probability produces a 4.2% edge, making the over the favorable side in Saturday’s matchup.

Athletics vs. Angels over 9.5 runs (+104)

• Edge: 3.5%
• Probability: 52.5%
• Matchup: Athletics vs. Angels (9:38PM ET, Wednesday)

Rounding out our top 10 bets, Athletics vs. Angels over 9.5 runs at +104 odds shows a 52.5% probability and a 3.5% edge.

MLB best bets summary: Wednesday, 5/20/2026

As of 4:06AM ET, here are our top MLB bets by edge recommended by our model:

List of upcoming MLB games to bet on [5/20/2026]

• Reds vs. Phillies (1:05PM ET, Wednesday)
• Orioles vs. Rays (1:10PM ET, Wednesday)
• Astros vs. Twins (1:40PM ET, Wednesday)
• Rangers vs. Rockies (3:10PM ET, Wednesday)
• Giants vs. D-Backs (3:40PM ET, Wednesday)
• White Sox vs. Mariners (4:10PM ET, Wednesday)
• Braves vs. Marlins (6:40PM ET, Wednesday)
• Mets vs. Nationals (6:45PM ET, Wednesday)
• Blue Jays vs. Yankees (7:05PM ET, Wednesday)
• Brewers vs. Cubs (7:40PM ET, Wednesday)
• Red Sox vs. Royals (7:40PM ET, Wednesday)
• Pirates vs. Cardinals (7:45PM ET, Wednesday)
• Dodgers vs. Padres (8:40PM ET, Wednesday)
• Athletics vs. Angels (9:38PM ET, Wednesday)

Conclusion

Our MLB best bets are locked and loaded for May 20, 2026, featuring plays such as over 6.5 runs in the Brewers vs. Cubs matchup and over 7.5 runs in the Dodgers vs. Padres matchup. Powered by advanced simulations, these picks are here to boost your betting game.

Our predictions are based on current data to help you make informed decisions. For additional resources and advice, head to our Responsible Gambling hub.

All odds and probabilities in this article are correct and accurate at the time of publication.