Guardians vs. Tigers Prediction, Picks and Odds

Our detailed prediction and analysis for the Guardians vs. Tigers MLB game on May 21, 2026 is featured below. Drawing from 10,000 game simulations, we provide expert picks, betting odds, and insights.
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MLB
Guardians
Joey Cantillo 3-1, 3.40 ERA
3
1
Comerica Park
Tigers
Casey Mize 2-2, 2.43 ERA
Comerica Park
1 2 3 4 5 6 7 8 9 RHE
Guardians
0 0 2 0 0 0 0 1 0 3 6 0
Tigers
0 0 0 0 0 0 0 1 0 1 6 0
Live Probabilities
Win %
  • Guardians
    100%
  • Tigers
    0%
Win Probability
Baseball infield diamond diagram
Last At Bat
Outs
Matt Vierling strikes out swinging.
Quick Box Score
Guardians Hitting
No.PlayerPosABRHRBIHRBBSOAVGOPS
1 D. Schneemann 3B3111011.3331.167
2 J. Ramírez DH4011001.2500.500
3 C. DeLauter RF4000001.0000.000
4 R. Hoskins 1B4000001.0000.000
5 T. Bazzana 2B4000001.0000.000
6 A. Martínez LF4000001.0000.000
7 S. Kwan CF4000001.0000.000
8 P. Bailey C3111100.3331.666
9 B. Rocchio SS31300001.0002.667
Tigers Hitting
No.PlayerPosABRHRBIHRBBSOAVGOPS
1 M. Vierling CF4000013.0000.200
2 K. McGonigle SS3010011.3330.833
3 D. Dingler C4121102.5002.000
4 R. Greene LF4000002.0000.000
5 G. Workman DH1000001.0000.000
6 S. Torkelson 1B4010000.2500.500
7 W. Pérez RF4000001.0000.000
8 C. Keith 3B1000011.0000.500
9 Z. McKinstry 2B2010001.5001.000

Guardians vs. Tigers: Detailed Breakdown

Matchup Overview

  • Teams: Guardians vs. Tigers
  • Date: Thursday, May 21, 2026
  • Time: 1:10 PM ET
  • Venue: Comerica Park

Current Betting Odds

  • Spread: Tigers favored at -1.5
  • Total (Over/Under): 7.5
  • Moneyline Odds: Guardians 46¢, Tigers 53¢

Dimers' Win Probabilities

  • Guardians: 47%
  • Tigers: 53%

Dimers' predictive model, renowned for its accuracy, assesses each team's chances by simulating the outcome of the game 10,000 times. This method provides a precise and unbiased view.

Our Prediction: Who Wins?

After extensive simulations, our model gives the Guardians a win probability of 47%, while the Tigers have a win probability of 53%. Discover the best spread, over/under, and moneyline odds for the game on this page.

Summary

According to our analysis, the Tigers are more likely to beat the Guardians in the MLB game at Comerica Park on Thursday. Discover the best spread, over/under and moneyline odds, picks and probabilities for the game on this page.

Our Guardians vs. Tigers predictions, based on sophisticated simulations and current data, guide you in making informed decisions. Remember to bet responsibly and within your financial limits.

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For further insights, explore our expert MLB predictions and the best MLB bets today, while our in-depth analysis includes MLB props, MLB futures, MLB odds, and the latest MLB news.