Pirates vs. Cardinals Prediction, Picks and Odds

Our detailed prediction and analysis for the Pirates vs. Cardinals MLB game on May 21, 2026 is featured below. Drawing from 10,000 game simulations, we provide expert picks, betting odds, and insights.
FINAL
MLB
Add this game to My Favorites
FINAL
Add this game to My Favorites
MLB sport icon
MLB
Pirates
Braxton Ashcraft 2-2, 3.09 ERA
6
2
May 21, 1:15 PM ET Busch Stadium
Cardinals
Dustin May 3-4, 4.81 ERA
May 21, 1:15 PM ET Busch Stadium
1 2 3 4 5 6 7 8 9 RHE
Pirates
1 0 0 1 0 2 2 0 0 6 10 0
Cardinals
0 0 1 0 0 0 0 1 0 2 8 0
Live Probabilities
Win %
  • Pirates
    100%
  • Cardinals
    0%
Win Probability
Baseball infield diamond diagram
Last At Bat
Outs
Yohel Pozo grounds out to shallow infield. Pedro Pagés out at second.
Quick Box Score
Pirates Hitting
No.PlayerPosABRHRBIHRBBSOAVGOPS
1 O. Cruz CF5110003.2000.600
2 B. Lowe 2B4121110.5001.850
3 B. Reynolds LF5001003.0000.000
4 S. Horwitz 1B3110010.3330.833
5 K. Griffin SS4210000.2500.750
6 M. Ozuna DH4022000.5001.000
7 J. Mangum RF4011001.2500.500
8 J. Triolo 3B4010001.2500.500
9 H. Davis C3111101.3331.833
Cardinals Hitting
No.PlayerPosABRHRBIHRBBSOAVGOPS
1 J. Wetherholt 2B4000002.0000.000
2 I. Herrera DH4221102.5001.750
3 A. Burleson 1B4020002.5001.250
4 J. Walker RF4011001.2500.500
5 N. Gorman 3B4000003.0000.000
6 M. Winn SS2000021.0000.500
7 J. Fermín LF4010000.2500.500
8 P. Pagés C4020000.5001.000
9 Y. Pozo PH1000000.0000.000

Pirates vs. Cardinals: Detailed Breakdown

Matchup Overview

  • Teams: Pirates vs. Cardinals
  • Date: Thursday, May 21, 2026
  • Time: 1:15 PM ET
  • Venue: Busch Stadium

Current Betting Odds

  • Spread: Pirates favored at -1.5
  • Total (Over/Under): 7.5
  • Moneyline Odds: Pirates -106, Cardinals +108

Dimers' Win Probabilities

  • Pirates: 58%
  • Cardinals: 42%

Dimers' predictive model, renowned for its accuracy, assesses each team's chances by simulating the outcome of the game 10,000 times. This method provides a precise and unbiased view.

Our Prediction: Who Wins?

After extensive simulations, our model gives the Pirates a win probability of 58%, while the Cardinals have a win probability of 42%. Discover the best spread, over/under, and moneyline odds for the game on this page.

Summary

According to our analysis, the Pirates are more likely to beat the Cardinals in the MLB game at Busch Stadium on Thursday. Discover the best spread, over/under and moneyline odds, picks and probabilities for the game on this page.

Our Pirates vs. Cardinals predictions, based on sophisticated simulations and current data, guide you in making informed decisions. Remember to bet responsibly and within your financial limits.

For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

When you click or tap on a link on Dimers that goes to a third-party website that we have a commercial relationship with (such as a sportsbook), we may receive a referral fee.

For further insights, explore our expert MLB predictions and the best MLB bets today, while our in-depth analysis includes MLB props, MLB futures, MLB odds, and the latest MLB news.