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Pirates vs. Cardinals Prediction, Picks and Odds
Our detailed prediction and analysis for the Pirates vs. Cardinals MLB game on May 21, 2026 is featured below. Drawing from 10,000 game simulations, we provide expert picks, betting odds, and insights.
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MLB
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MLB
6
2
May 21, 5:15PM Busch Stadium
May 21, 5:15PM Busch Stadium
In-Play ProbabilitiesIn-Play
Game PredictionsPre-Game
Bets
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | R | H | E | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Pirates | 1 | 0 | 0 | 1 | 0 | 2 | 2 | 0 | 0 | 6 | 10 | 0 |
Cardinals | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 2 | 8 | 0 |
Live Probabilities
Moneyline
Over / Under
Run Line
Win %
100%
0%
Win Probability
Last At Bat
Outs
Yohel Pozo grounds out to shallow infield. Pedro Pagés out at second.
Quick Box Score
Hitting
Pitching
| No. | Player | Pos | AB | R | H | RBI | HR | BB | SO | AVG | OPS |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | O. Cruz | CF | 5 | 1 | 1 | 0 | 0 | 0 | 3 | .200 | 0.600 |
| 2 | B. Lowe | 2B | 4 | 1 | 2 | 1 | 1 | 1 | 0 | .500 | 1.850 |
| 3 | B. Reynolds | LF | 5 | 0 | 0 | 1 | 0 | 0 | 3 | .000 | 0.000 |
| 4 | S. Horwitz | 1B | 3 | 1 | 1 | 0 | 0 | 1 | 0 | .333 | 0.833 |
| 5 | K. Griffin | SS | 4 | 2 | 1 | 0 | 0 | 0 | 0 | .250 | 0.750 |
| 6 | M. Ozuna | DH | 4 | 0 | 2 | 2 | 0 | 0 | 0 | .500 | 1.000 |
| 7 | J. Mangum | RF | 4 | 0 | 1 | 1 | 0 | 0 | 1 | .250 | 0.500 |
| 8 | J. Triolo | 3B | 4 | 0 | 1 | 0 | 0 | 0 | 1 | .250 | 0.500 |
| 9 | H. Davis | C | 3 | 1 | 1 | 1 | 1 | 0 | 1 | .333 | 1.833 |
| No. | Player | Pos | AB | R | H | RBI | HR | BB | SO | AVG | OPS |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | J. Wetherholt | 2B | 4 | 0 | 0 | 0 | 0 | 0 | 2 | .000 | 0.000 |
| 2 | I. Herrera | DH | 4 | 2 | 2 | 1 | 1 | 0 | 2 | .500 | 1.750 |
| 3 | A. Burleson | 1B | 4 | 0 | 2 | 0 | 0 | 0 | 2 | .500 | 1.250 |
| 4 | J. Walker | RF | 4 | 0 | 1 | 1 | 0 | 0 | 1 | .250 | 0.500 |
| 5 | N. Gorman | 3B | 4 | 0 | 0 | 0 | 0 | 0 | 3 | .000 | 0.000 |
| 6 | M. Winn | SS | 2 | 0 | 0 | 0 | 0 | 2 | 1 | .000 | 0.500 |
| 7 | J. Fermín | LF | 4 | 0 | 1 | 0 | 0 | 0 | 0 | .250 | 0.500 |
| 8 | P. Pagés | C | 4 | 0 | 2 | 0 | 0 | 0 | 0 | .500 | 1.000 |
| 9 | Y. Pozo | PH | 1 | 0 | 0 | 0 | 0 | 0 | 0 | .000 | 0.000 |
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Pirates vs. Cardinals: Detailed Breakdown
Matchup Overview
- Teams: Pirates vs. Cardinals
- Date: Thursday, May 21, 2026
- Time: 1:15 PM ET
- Venue: Busch Stadium
Current Betting Odds
- Spread: Pirates favored at -1.5
- Total (Over/Under): 7.5
- Moneyline Odds: Pirates -106, Cardinals +108
Dimers' Win Probabilities
- Pirates: 58%
- Cardinals: 42%
Dimers' predictive model, renowned for its accuracy, assesses each team's chances by simulating the outcome of the game 10,000 times. This method provides a precise and unbiased view.
Our Prediction: Who Wins?
After extensive simulations, our model gives the Pirates a win probability of 58%, while the Cardinals have a win probability of 42%. Discover the best spread, over/under, and moneyline odds for the game on this page.
Summary
According to our analysis, the Pirates are more likely to beat the Cardinals in the MLB game at Busch Stadium on Thursday. Discover the best spread, over/under and moneyline odds, picks and probabilities for the game on this page.
Our Pirates vs. Cardinals predictions, based on sophisticated simulations and current data, guide you in making informed decisions. Remember to bet responsibly and within your financial limits.
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For further insights, explore our expert MLB predictions and the best MLB bets today, while our in-depth analysis includes MLB props, MLB futures, MLB odds, and the latest MLB news.
