White Sox vs. Yankees Prediction and Odds - May 22, 2022

The New York Yankees take on the Chicago White Sox at Yankee Stadium on Sunday, commencing at 7:08PM ET.

The Yankees will have Jameson Taillon (4-1, 3.28 ERA) start, while the White Sox are going with Michael Kopech (0-1, 1.54 ERA).

Dimers' best betting picks for White Sox vs. Yankees, plus game predictions and best odds, are featured below.

Today's CHI White Sox vs. NY Yankees betting analysis is proudly sponsored by PointsBet, which has an awesome 5x $100 Risk-Free Bets offer for new customers.

Who will win White Sox vs. Yankees?

Based on advanced computer power and data, Dimers.com has simulated Sunday's White Sox-Yankees MLB game 10,000 times.

Dimers' renowned predictive analytics model, DimersBOT, gives the Yankees a 62% chance of winning against the White Sox .

More: White Sox vs. Yankees Simulated 10K Times

White Sox vs. Yankees Game Odds

• Run Line: Yankees -1.5 (+120), White Sox +1.5 (-125)
• Moneyline: Yankees -160, White Sox +160
• Total: Over/Under 9 (-105/+100)

Run Line, Moneyline and Over/Under

The Yankees are listed as -1.5 favorites versus the White Sox, with +120 at BetMGM the best odds currently available.

For the underdog White Sox (+1.5) to cover the run line, Caesars Sportsbook has the best odds currently on offer at -125.

BetMGM currently has the best moneyline odds for the Yankees at -160, which means you can risk $160 to win $100, for a total payout of $260, if they get the W.

On the other hand, Caesars Sportsbook currently has the best moneyline odds for the White Sox at +160, where you can bet $100 to profit $160, earning a total payout of $260, if they win.

The Over/Under sits at 9 with PointsBet, which currently has the best odds for the Over at -105, while Caesars Sportsbook currently has the best odds for the Under at +100.

As always, make sure you check the sportsbooks you have access to in your state for the best MLB odds and lines.

According to DimersBOT, the White Sox (+1.5) are a 55% chance of covering the run line, while the 9-run Over/Under is considered an equal 50-50 chance of hitting.

More: Free Prop Picks

Best Bets for White Sox vs. Yankees

• Run Line: White Sox +1.5 @ -125 via Caesars Sportsbook (55% probability)
• Moneyline: Yankees @ -160 via BetMGM (62% probability)
• Total: Under 9 @ +100 via Caesars Sportsbook (50% probability)

Dimers' best bets are based on detailed simulations and betting intelligence to help you make more informed decisions with the legal sportsbooks in the USA.

White Sox vs. Yankees Probabilities

Use our dynamic widget below to see up-to-date Moneyline, Over/Under and Run Line probabilities and odds for CHI White Sox vs. NY Yankees, and click or tap on See Matchup to reveal more.

Dimers has full coverage of Sunday's White Sox-Yankees matchup, including pregame predictions, free picks, and live updates.

Remember, DimersBOT updates regularly, so refresh this article for any changes to our betting analysis ahead of White Sox vs. Yankees on Sunday May 22, 2022.

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Note: when you click or tap on a link on Dimers that leads to a third-party website that we have a commercial arrangement with (such as a sportsbook), we may earn a referral fee.

White Sox vs. Yankees 2022 Game Info

Sunday's game between the Yankees and White Sox at Yankee Stadium is scheduled to start at 7:08PM ET.

• Date: Sunday May 22, 2022
• Time: 7:08PM ET / 4:08PM PT
• Venue: Yankee Stadium

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Want more MLB analysis like this?

To get more MLB betting predictions like you've just read for White Sox vs. Yankees, all you've gotta do is visit Dimers' MLB Betting News page. It's that easy – they're all there!

We use the power of predictive analytics to find value in the markets so we can write the best MLB betting previews available. We're able to do this by comparing our in-house probabilities against the sportsbooks' odds (aka Vegas odds) as soon as they go live.

So, get ahead of the game and beat the bookies today – it's only a click away.

Lastly, Dimers' Baseball Futures page is our in-house approach to revealing who will win the 2022 World Series, with our data-led probabilities matched against the best odds available.