White Sox vs. Yankees Prediction and Odds - May 21, 2022

The New York Yankees take on the Chicago White Sox at Yankee Stadium on Saturday, beginning at 1:05PM ET.

The Yankees will send Nestor Cortes (2-1, 1.35 ERA) to the mound, up against Dallas Keuchel (2-3, 5.54 ERA) for the White Sox.

Dimers' best betting picks for White Sox vs. Yankees, plus game predictions and best odds, are detailed in this article.

Today's CHI White Sox vs. NY Yankees betting analysis is proudly sponsored by PointsBet, which has a tasty 5x $100 Risk-Free Bets offer for new users.

Who will win White Sox vs. Yankees?

Using cutting-edge computer power and data, Dimers.com has simulated Saturday's White Sox-Yankees MLB matchup 10,000 times.

Dimers' popular predictive analytics model, DimersBOT, currently gives the Yankees a 63% chance of winning against the White Sox .

More: White Sox vs. Yankees Simulated 10K Times

White Sox vs. Yankees Game Odds

• Run Line: Yankees -1.5 (-115), White Sox +1.5 (+100)
• Moneyline: Yankees -222, White Sox +190
• Total: Over/Under 9 (-120/+105)

Run Line, Moneyline and Over/Under

The Yankees are currently -1.5 favorites versus the White Sox, with -115 at BetMGM the best odds currently available.

For the underdog White Sox (+1.5) to cover the run line, DraftKings Sportsbook has the best odds currently on offer at +100.

Caesars Sportsbook currently has the best moneyline odds for the Yankees at -222, which means you can risk $222 to win $100, for a total payout of $322, if they get the W.

On the other hand, DraftKings Sportsbook currently has the best moneyline odds for the White Sox at +190, where you can bet $100 to profit $190, earning a total payout of $290, if they win.

The Over/Under for total runs scored sits at 9 with BetMGM, which currently has the best odds for the Over at -120, while DraftKings Sportsbook currently has the best odds for the Under at +105.

As always, check out all the sportsbooks that are available in your state for the best MLB odds and lines.

According to DimersBOT, the White Sox (+1.5) are a 53% chance of covering the run line, while the 9-run Over/Under is a 54% chance of going Over.

More: Free Prop Picks

Best Bets for White Sox vs. Yankees

• Run Line: White Sox +1.5 @ +100 via DraftKings Sportsbook (53% probability)
• Moneyline: White Sox @ +190 via DraftKings Sportsbook (2.2% edge)
• Total: Over 9 @ -120 via BetMGM (54% probability)

Dimers' best bets are based on world-class simulations and wagering intelligence to bring you the best possible plays every time.

While the Yankees are more likely to win the game, according to DimersBOT, taking the White Sox moneyline is the best option because of the 2.2% edge found when comparing our data-led probabilities to the betting odds currently on offer.

Taking advantage of the edges seen here at Dimers.com is crucial to being a profitable bettor in the long run.

White Sox vs. Yankees Betting Guide

Use our dynamic widget below to explore the latest Moneyline, Over/Under and Run Line probabilities and odds for CHI White Sox vs. NY Yankees, and click or tap on See Matchup for more.

Dimers has full coverage of Saturday's White Sox-Yankees matchup, including pregame predictions, best betting picks, and live win probabilities.

Don't forget, DimersBOT updates often, so check this article for any changes to our betting insights before White Sox vs. Yankees on Saturday May 21, 2022.

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Note: when you click or tap on a link on Dimers that leads to a third-party website that we have a commercial arrangement with (such as a sportsbook), we may earn a referral fee.

White Sox vs. Yankees 2022 Game Info

Saturday's game between the Yankees and White Sox at Yankee Stadium is scheduled to start at 1:05PM ET.

• Date: Saturday May 21, 2022
• Time: 1:05PM ET / 10:05AM PT
• Venue: Yankee Stadium

Looking to join an online sportsbook and start betting on MLB today? Check out the top sportsbook offers in your state.

What other MLB games are on today?

The White Sox and Yankees aren't the only two MLB teams you can bet on. DimersBOT never stops and we've got picks and best bets for each and every MLB game via our MLB Predictions section.

Not only do we provide with you quality predictions, but we also have recommended bets for the Run Line, Over/Under and Moneyline. Sound good? Check it out now!

Finally, Dimers' Baseball Futures page is our in-house approach to determining who will win the 2022 World Series, with our data-led probabilities compared to the best odds available.