Twins vs. Royals Prediction and Odds - May 21, 2022

The Kansas City Royals take on the Minnesota Twins in MLB action at Kauffman Stadium on Saturday, commencing at 7:10PM ET.

The Royals will have Brad Keller (1-3, 2.88 ERA) start, pitting him against Joe Ryan (4-2, 2.39 ERA) for the Twins.

Dimers' best betting picks for Twins vs. Royals, as well as game predictions and best odds, are featured below.

This Minnesota vs. Kansas City betting analysis is sponsored by PointsBet, which has a great 5x $100 Risk-Free Bets promo for new customers.

Who will win Twins vs. Royals?

Based on state-of-the-art machine learning and data, Dimers.com has simulated Saturday's Twins-Royals MLB game 10,000 times.

Dimers' famous predictive analytics model, DimersBOT, currently gives the Twins a 56% chance of getting the W against the Royals .

More: Full Betting Guide for Twins vs. Royals

Twins vs. Royals Current Odds

• Run Line: Royals +1.5 (-135), Twins -1.5 (+115)
• Moneyline: Royals +130, Twins -149
• Total: Over/Under 7.5 (+110/-120)

Run Line, Moneyline and Over/Under

The Royals are +1.5 underdogs against the Twins, with -135 at DraftKings Sportsbook the best odds currently available.

For the favored Twins (-1.5) to cover the run line, BetMGM has the best odds currently on offer at +115.

DraftKings Sportsbook currently has the best moneyline odds for the Royals at +130, which means you can bet $100 to profit $130, earning a total payout of $230, if they win.

Meanwhile, Caesars Sportsbook currently has the best moneyline odds for the Twins at -149, where you can risk $149 to win $100, for a total payout of $249, if they come out on top.

The Over/Under sits at 7.5 with Caesars Sportsbook, which currently has the best odds for the Over at +110, while BetMGM currently has the best odds for the Under at -120.

As always, make sure you check all the online sportsbooks that are available in your state for the best MLB odds and lines.

According to DimersBOT, the Royals (+1.5) are a 57% chance of covering the run line, while the Over/Under total of 7.5 runs is considered an equal 50-50 chance of hitting.

More: Free Prop Picks

Best Bets for Twins vs. Royals

• Run Line: Royals +1.5 @ -135 via DraftKings Sportsbook (57% probability)
• Moneyline: Royals @ +130 via DraftKings Sportsbook (0.4% edge)
• Total: Over 7.5 @ +110 via Caesars Sportsbook (50% probability)

Dimers' best bets are based on world-class simulations and betting intelligence to help you make more informed decisions with the legal sportsbooks in the USA.

While the Twins are more likely to win the game, according to DimersBOT, betting on the Royals moneyline is the best option because of the edge identified when comparing our data-led probabilities to the sportsbooks' odds currently on offer.

Taking advantage of the edges published on Dimers is pivotal to achieving long-term profitability as a bettor.

Twins vs. Royals Betting Guide

Use our dynamic widget below to view up-to-date Moneyline, Over/Under and Run Line probabilities and odds for Minnesota vs. Kansas City, and click or tap on See Matchup for more.

Dimers has full betting coverage of Saturday's Twins-Royals matchup, including pregame predictions, top betting picks, and live win probabilities.

Don't forget, DimersBOT updates often, so refresh this page for any changes to our betting analysis ahead of Twins vs. Royals on Saturday May 21, 2022.

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Note: when you click or tap on a link on Dimers that leads to a third-party website that we have a commercial arrangement with (such as a sportsbook), we may earn a referral fee.

Twins vs. Royals 2022 Game Info

Saturday's action between the Royals and Twins at Kauffman Stadium is scheduled to commence at 7:10PM ET.

• Date: Saturday May 21, 2022
• Time: 7:10PM ET / 4:10PM PT
• Venue: Kauffman Stadium

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Want more MLB predictions like this?

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We use the power of predictive analytics to find edges in the markets so we can publish the best MLB betting previews out there. We're able to do this by comparing our own probabilities against the sportsbooks' odds (aka Vegas odds) the minute they go live.

So, get ahead of the game and beat the bookies today – it's only a click away.

Lastly, Dimers' Baseball Futures page is our in-house approach to determining who will win the 2022 World Series, with our data-led probabilities matched against the best odds available.