Twins vs. Guardians Prediction and Odds - Sep 16, 2022

The Cleveland Guardians and Minnesota Twins lock horns in MLB at Progressive Field on Friday, starting at 7:10PM ET.

Triston McKenzie (10-11, 3.05 ERA) will be on the bump for the Guardians, pitting him against Bailey Ober (1-2, 4.01 ERA) for the Twins.

Dimers' free betting picks for Twins vs. Guardians, as well as game predictions and best odds, are detailed in this article.

Who will win Twins vs. Guardians?

Using state-of-the-art computer power and data, Dimers.com has simulated Friday's Twins-Guardians MLB matchup 10,000 times.

Dimers' popular predictive analytics model, DimersBOT, gives the Guardians a 59% chance of beating the Twins.

More: Full Betting Guide for Twins vs. Guardians

Twins vs. Guardians Game Odds

• Run Line: Guardians -1.5 (+150), Twins +1.5 (-160)
• Moneyline: Guardians -145, Twins +140
• Total: Over/Under 7.5 (-105/-105)

Run Line, Moneyline and Over/Under

The Guardians are currently -1.5 favorites versus the Twins, with +150 at Caesars Sportsbook the best odds currently available.

For the underdog Twins (+1.5) to cover the run line, FanDuel Sportsbook has the best odds currently on offer at -160.

Caesars Sportsbook currently has the best moneyline odds for the Guardians at -145. That means you can risk $145 to win $100, for a total payout of $245, if they get the W.

Elsewhere, FanDuel Sportsbook currently has the best moneyline odds for the Twins at +140, where you can bet $100 to profit $140, earning a total payout of $240, if they win.

The Over/Under sits at 7.5 with DraftKings Sportsbook, which currently has the best odds for the Over at -105, while BetMGM currently has the best odds for the Under at -105.

As always, check out all of the online sportsbooks available in your state for the best MLB odds and lines.

According to DimersBOT, the Twins (+1.5) are a 60% chance of covering the run line, while the 7.5-run Over/Under is a 55% chance of going Over.

More: Free Prop Picks

Best Bets for Twins vs. Guardians

• Run Line: Guardians -1.5 @ +150 via Caesars Sportsbook (0.3% edge)
• Moneyline: Guardians @ -145 via Caesars Sportsbook (59% probability)
• Total: Over 7.5 @ -105 via DraftKings Sportsbook (55% probability)

Dimers' best bets are based on complex modeling and gambling expertise to help you make better investments with your state's legal sportsbooks.

Although the Twins are more likely to cover the run line, our best bet of Guardians -1.5 is based on the chance of that happening, according to DimersBOT, and the best odds available.

Twins vs. Guardians Probabilities

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Dimers has full coverage of Friday's Twins-Guardians matchup, including pregame predictions, best betting picks, and live win probabilities.

Don't forget, DimersBOT updates regularly, so keep an eye on this page for the latest betting insights before Twins vs. Guardians on Friday September 16, 2022.

Twins vs. Guardians 2022 Game Info

Friday's game between the Guardians and Twins at Progressive Field is scheduled to start at 7:10PM ET.

• Who: Minnesota Twins vs. Cleveland Guardians
• Date: Friday September 16, 2022
• Time: 7:10PM ET / 4:10PM PT
• Venue: Progressive Field

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