Tigers vs. Guardians Prediction and Odds - May 22, 2022

MLB action continues on Sunday at 1:40PM ET as the Detroit Tigers square off with the Cleveland Guardians at Progressive Field.

The Guardians will send Shane Bieber (1-2, 3.72 ERA) to the mound, pitting him against Alex Faedo (0-1, 2.87 ERA) for the Tigers.

Dimers' top betting picks for Tigers vs. Guardians, as well as game predictions and best odds, are featured below.

Today's Detroit vs. Cleveland betting preview is presented by PointsBet, which has a 5x $100 Risk-Free Bets promo for new customers.

Who will win Tigers vs. Guardians?

Based on advanced computer power and data, Dimers.com has simulated Sunday's Tigers-Guardians MLB game 10,000 times.

Dimers' popular predictive analytics model, DimersBOT, currently gives the Guardians a 66% chance of beating the Tigers .

More: Tigers vs. Guardians Simulated 10,000 Times

Tigers vs. Guardians Game Odds

• Run Line: Guardians -1.5 (+116), Tigers +1.5 (-135)
• Moneyline: Guardians -185, Tigers +165
• Total: Over/Under 7 (-115/+100)

Run Line, Moneyline and Over/Under

The Guardians are -1.5 favorites against the Tigers, with +116 at FanDuel Sportsbook the best odds currently available.

For the underdog Tigers (+1.5) to cover the run line, BetMGM has the best odds currently on offer at -135.

Caesars Sportsbook currently has the best moneyline odds for the Guardians at -185, which means you can risk $185 to win $100, for a total payout of $285, if they get the W.

On the other hand, Caesars Sportsbook also has the best moneyline odds for the Tigers at +165, where you can put down $100 to profit $165, earning a total payout of $265, if they win.

The Over/Under for total runs scored sits at 7 with BetMGM, which currently has the best odds for the Over at -115, while PointsBet currently has the best odds for the Under at +100.

As always, check out all the legal sportbooks available in your state for the best MLB odds and lines.

According to DimersBOT, the Tigers (+1.5) are a 53% chance of covering the run line, while the 7-run Over/Under is a 53% chance of going Over.

More: Free Prop Picks

Best Bets for Tigers vs. Guardians

• Run Line: Guardians -1.5 @ +116 via FanDuel Sportsbook (0.6% edge)
• Moneyline: Guardians @ -185 via Caesars Sportsbook (66% probability)
• Total: Over 7 @ -115 via BetMGM (53% probability)

Dimers' best bets are based on complex simulations and wagering intelligence to bring you the best possible plays every day of the year.

Although the Tigers are more likely to cover the run line, our best bet of Guardians -1.5 is based on the likelihood of that happening, according to DimersBOT, and the best odds available.

Tigers vs. Guardians Betting Guide

Use our interactive widget below to view up-to-date Moneyline, Over/Under and Run Line probabilities and odds for Detroit vs. Cleveland, and click or tap on See Matchup to reveal more.

Dimers has full coverage of Sunday's Tigers-Guardians matchup, including pregame predictions, free picks, and live win probabilities.

Don't forget, DimersBOT updates regularly, so keep an eye on this article for any changes to our betting insights before Tigers vs. Guardians on Sunday May 22, 2022.

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Tigers vs. Guardians 2022 Game Info

Sunday's matchup between the Guardians and Tigers at Progressive Field is scheduled to begin at 1:40PM ET.

• Date: Sunday May 22, 2022
• Time: 1:40PM ET / 10:40AM PT
• Venue: Progressive Field

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What MLB games are on today?

Now you've got the 411 on Tigers vs. Guardians, get the latest betting predictions for all upcoming MLB games in Dimers' MLB Bet Hub, where you can find probabilities and odds, and our best bets for every single MLB matchup.

Want a pick for the Run Line? You got it. How about the Over/Under? Yup, got that too. The Moneyline? Yes sir. And these picks are good, I mean REALLY good. Take a look now!

Lastly, Dimers' Baseball Futures page is our in-house approach to determining who will win the 2022 World Series, with our data-led probabilities matched against the best odds on the market.