San Francisco Giants vs. Pittsburgh Pirates Prediction, Odds, MLB Picks [5/22/2024]

San Francisco Giants vs. Pittsburgh Pirates Prediction, Odds, MLB Picks [5/22/2024]

The Pittsburgh Pirates will square off with the San Francisco Giants in MLB action at PNC Park on Wednesday, beginning at 6:40PM ET.

The Pirates will have Jared Jones (3-4, 2.89 ERA) as their starting pitcher, while the Giants are going with Blake Snell (0-3, 11.57 ERA).'s comprehensive preview of Wednesday's Giants vs. Pirates matchup includes our prediction, picks and the latest betting odds.

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Giants vs. Pirates Prediction: Who Will Win, Cover the Run Line

We have used powerful machine learning and statistics to simulate the result of Wednesday's MLB game between the Giants and Pirates 10,000 times, in line with our coverage of MLB picks.

Our famous predictive analytics model currently gives the Pirates a 53% chance of defeating the Giants.

According to our model, the Giants (+1.5) have a 66% chance of covering the run line, while the 7.5-run over/under has a 54% chance of going under.

Giants vs. Pirates Odds [5/22/2024]

We have sourced the best betting odds in America for this game, which are listed here:

Bet Type Giants Pirates
Run Line +1.5 (-200) -1.5 (+170)
Moneyline +105 -120
Total o7.5 (-102) u7.5 (-118)

All odds are correct at the time of publication and are subject to change.

Giants vs. Pirates Picks

At Dimers, our predictions, paired with the current odds, reveal the top betting picks to make on every game, including Giants vs. Pirates. Our best MLB bets are based on expert modeling and analysis, as you can see.

Dimers Pro gives sports bettors an edge. Through Dimers Pro, we give you the tools and information to succeed with hundreds of data-driven bets across thousands of games. Join now to find any potential picks for this matchup.


Giants vs. Pirates Game Information

Wednesday's MLB action between the Pirates and Giants at PNC Park is scheduled to commence at 6:40PM ET.


Our full betting coverage of the Giants vs. Pirates includes pregame predictions, betting picks and live scores.

Calling Our Shot: Free ⚾️ Picks

Calling Our Shot produces daily MLB betting content, including the latest free picks featured below.


We predict the Pirates, with a 53% win probability, will likely beat the Giants on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Giants vs. Pirates insights, with human oversight ensuring high editorial quality. Our predictions are drawn from current data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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Dave Garofolo
Content Producer

Dave Garofolo, a seasoned fantasy sports and betting enthusiast with a special affection for MLB and NFL, uses his deep knowledge to craft game previews for the NBA, MLB, and NFL. He also brings his expertise to the golf world with tournament previews and parlays for the PGA TOUR and major golf tournaments. Additionally, Dave offers valuable props for NBA, MLB, NHL, and NCAAM basketball, along with best bets for MLB, NHL, and NCAAM. 

When not delving into the world of sports, Dave is an avid advocate for New Haven pizza, enjoys reading comic books, gardening, and spending time with his cats. His broad interests and detailed sports insights ensure that his contributions are both engaging and informative.

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