Reilly Opelka vs. John Isner Predictions - Apr 10, 2022

Reilly Opelka and John Isner clash in the final of the 2022 ATP Houston event on Sunday.

Dimers' best betting picks for Opelka vs. Isner, as well as match predictions and best odds, are featured in this article.

Who will win Opelka vs. Isner?

Using trusted machine learning and data, Dimers.com has simulated Sunday's Opelka-Isner men's singles match 10,000 times.

Dimers' independent predictive analytics model, DimersBOT, currently gives Opelka a 58% chance of defeating Isner at the 2022 ATP Houston tournament.

MORE: Opelka vs. Isner 2022 Simulated 10K Times

H2H Moneyline and First Set

Caesars Sportsbook currently has the best moneyline odds for Opelka at -161. That means you can risk $161 to win $100, for a total payout of $261, if he gets the W.

Meanwhile, Unibet currently has the best moneyline odds for Isner at +148, where you can put down $100 to profit $148, earning a total payout of $248, if he wins.

Caesars Sportsbook currently has the best odds for Opelka to win the first set at -143, while Unibet currently has the best odds for Isner to win the first set at +130.

As always, make sure you check the sportsbooks you can bet with in your state for the best Tennis odds in the USA.

According to DimersBOT, Opelka is a 55% chance of winning the first set versus Isner.

MORE: Live Scores for All Major Sports

Best Bets for Opelka vs. Isner

• Moneyline: Isner @ +148 via Unibet (2.3% edge)
• First Set: Isner @ +130 via Unibet (1.3% edge)

Dimers' best bets are based on world-class simulations and betting intelligence to serve you the best possible plays every day of the year.

Even though Opelka is more likely to win the match, according to DimersBOT, taking Isner moneyline is our preferred option due to the 2.3% edge found when comparing our data-led probabilities to the betting odds currently available.

Taking advantage of the edges published here at Dimers is crucial to being profitable in the long run.

And while Opelka is more likely to win the first set on this occassion, our suggested bet of Isner (+130) is based on the expectation of that happening, according to DimersBOT, and the best odds currently available.

Opelka vs. Isner Betting Tips

Use our widget below to explore up-to-date Moneyline and First Set probabilities and odds for the match, and click or tap on See Matchup to reveal more.

Dimers has full coverage of Reilly Opelka vs. John Isner, including pre-match predictions, computer picks, and live in-play probabilities.

Don't forget, DimersBOT updates often, so keep an eye on this page for the latest betting insights ahead of Opelka vs. Isner at the 2022 ATP Houston event.

Risk-Free Bet for Opelka vs. Isner

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Note: when you click or tap on a link on Dimers that leads to a third-party website that we have a commercial arrangement with (such as a sportsbook), we may earn a referral fee.

Opelka vs. Isner 2022 Match Preview

When does Reilly Opelka play John Isner at 2022 ATP Houston?

• Date: Sunday April 10, 2022
• Approx. Time: 3:00PM EDT / 12:00PM PDT
• Tournament: 2022 ATP Houston
• Round: Final

All days and times mentioned in this article are United States Eastern Time unless otherwise stated.

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What other Tennis matches are on today?

Now you've got the 411 on Reilly Opelka vs. John Isner, see the latest betting analysis for all upcoming Tennis matches in our Tennis Bet Hub, where you can find probabilities and odds, and our best bets for each and every Tennis matchup.

Want a Moneyline pick? You got it. How about the First Set? Yup, got that too. And these picks are good, I mean REALLY good. Take a look now!

While you're here, Dimers' Tennis World Rankings is our in-house approach to accurately ranking every men's and women's player in the world, overall and by court type, which is updated after every tournament.