Reds vs. Guardians Prediction and Odds - May 18, 2022

The Cleveland Guardians take on the Cincinnati Reds at Progressive Field on Wednesday, commencing at 6:10PM ET.

The Guardians will send Cal Quantrill (1-2, 3.93 ERA) to the mound, up against Tyler Mahle (2-4, 5.89 ERA) for the Reds.

Dimers' free betting picks for Reds vs. Guardians, as well as game predictions and best odds, are featured below.

Today's Cincinnati vs. Cleveland betting preview is sponsored by PointsBet, which has an awesome 5x $100 Risk-Free Bets offer for new customers.

Who will win Reds vs. Guardians?

Using trusted computer power and data, Dimers.com has simulated Wednesday's Reds-Guardians MLB matchup 10,000 times.

Dimers' renowned predictive analytics model, DimersBOT, gives the Guardians a 55% chance of winning against the Reds .

More: Reds vs. Guardians Simulated 10K Times

Reds vs. Guardians Current Odds

• Run Line: Guardians -1.5 (+160), Reds +1.5 (-182)
• Moneyline: Guardians -125, Reds +116
• Total: Over/Under 8 (+100/-110)

Run Line, Moneyline and Over/Under

The Guardians are -1.5 favorites against the Reds, with +160 at DraftKings Sportsbook the best odds currently available.

For the underdog Reds (+1.5) to cover the run line, FanDuel Sportsbook has the best odds currently on offer at -182.

DraftKings Sportsbook currently has the best moneyline odds for the Guardians at -125, which means you can risk $125 to win $100, for a total payout of $225, if they get the W.

Meanwhile, FanDuel Sportsbook currently has the best moneyline odds for the Reds at +116, where you can bet $100 to profit $116, earning a total payout of $216, if they win.

The Over/Under for total runs scored is set at 8 with Caesars Sportsbook, which currently has the best odds for the Over at +100, while DraftKings Sportsbook currently has the best odds for the Under at -110.

As always, make sure you check all the legal sportbooks available in your state for the best MLB odds and lines.

According to DimersBOT, the Reds (+1.5) are a 63% chance of covering the run line, while the Over/Under total of 8 runs is considered an equal 50-50 chance of hitting.

More: Free Prop Picks

Best Bets for Reds vs. Guardians

• Run Line: Guardians -1.5 @ +160 via DraftKings Sportsbook
• Moneyline: Guardians @ -125 via DraftKings Sportsbook (55% probability)
• Total: Over 8 @ +100 via Caesars Sportsbook (50% probability)

Dimers' best bets are based on complex simulations and wagering intelligence to bring you the best possible plays every time.

Even though the Reds are more likely to cover the run line, our best bet of Guardians -1.5 is based on the chance of that happening, according to DimersBOT, and the top odds available.

Reds vs. Guardians Probabilities

Use our dynamic widget below to see the latest Moneyline, Over/Under and Run Line probabilities and odds for Cincinnati vs. Cleveland, and click or tap on See Matchup to reveal more.

Dimers has full betting coverage of Wednesday's Reds-Guardians matchup, including pregame predictions, free picks, and live win probabilities.

Remember, DimersBOT updates regularly, so keep checking this page for any changes to our betting analysis before Reds vs. Guardians on Wednesday May 18, 2022.

Best Sportsbook Offer for Reds vs. Guardians

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Note: when you click or tap on a link on Dimers that leads to a third-party website that we have a commercial arrangement with (such as a sportsbook), we may earn a referral fee.

Reds vs. Guardians 2022 Game Info

Wednesday's game between the Guardians and Reds at Progressive Field is scheduled to start at 6:10PM ET.

• Date: Wednesday May 18, 2022
• Time: 6:10PM ET / 3:10PM PT
• Venue: Progressive Field

Ready to join an online sportsbook and start betting on MLB today? We've got access to the best available welcome offers in every legal betting state.

What other MLB games are on today?

Now you've got the 411 on Reds vs. Guardians, get the latest betting coverage for all upcoming MLB games in Dimers' MLB Bet Hub. There you can find probabilities and odds, as well as our best bets for every single MLB matchup.

Want a pick for the Run Line? You got it. How about the Over/Under? Yup, got that too. The Moneyline? Yes sir. And these picks are good, I mean REALLY good. Take a look now!

Finally, Dimers' MLB Futures page is our in-house approach to determining who will win the 2022 World Series, with our data-led probabilities compared to the best odds available.