Reds vs. Cardinals Prediction and Odds - Sep 16, 2022

The St. Louis Cardinals square off with the Cincinnati Reds in MLB action at Busch Stadium on Friday, commencing at 8:15PM ET.

Jack Flaherty (0-1, 4.50 ERA) will be on the bump for the Cardinals, while the Reds will counter with Fernando Cruz (0-0, 1.42 ERA).

Dimers' best betting picks for Reds vs. Cardinals, plus game predictions and best odds, are featured below.

Who will win Reds vs. Cardinals?

Using state-of-the-art machine learning and data, Dimers.com has simulated Friday's Reds-Cardinals MLB game 10,000 times.

Dimers' revolutionary predictive analytics model, DimersBOT, gives the Cardinals a 70% chance of winning against the Reds.

More: Reds vs. Cardinals Simulated 10K Times

Reds vs. Cardinals Game Odds

• Run Line: Cardinals -1.5 (-130), Reds +1.5 (+112)
• Moneyline: Cardinals -275, Reds +235
• Total: Over/Under 8.5 (+100/-115)

Run Line, Moneyline and Over/Under

The Cardinals are currently -1.5 favorites against the Reds, with -130 at Caesars Sportsbook the best odds currently available.

For the underdog Reds (+1.5) to cover the run line, FanDuel Sportsbook has the best odds currently on offer at +112.

BetMGM currently has the best moneyline odds for the Cardinals at -275, which means you can risk $275 to win $100, for a total payout of $375, if they get the W.

Elsewhere, FanDuel Sportsbook currently has the best moneyline odds for the Reds at +235, where you can bet $100 to profit $235, earning a total payout of $335, if they win.

The Over/Under sits at 8.5 with DraftKings Sportsbook, which currently has the best odds for the Over at +100, while Caesars Sportsbook currently has the best odds for the Under at -115.

As always, make sure you check all the online sportsbooks available in your state for the best MLB odds and lines.

According to DimersBOT, the Cardinals (-1.5) are a 53% chance of covering the run line, while the Over/Under total of 8.5 runs is a 51% chance of going Over.

More: Free Prop Picks

Best Bets for Reds vs. Cardinals

• Run Line: Reds +1.5 @ +112 via FanDuel Sportsbook
• Moneyline: Reds @ +235 via FanDuel Sportsbook (0.3% edge)
• Total: Over 8.5 @ +100 via DraftKings Sportsbook (51% probability)

Our best bets are based on detailed simulations and gambling expertise to help you make more informed investments with the legal sportsbooks in your state.

Although the Cardinals are more likely to cover the run line, our best bet of Reds +1.5 is based on the likelihood of that happening, according to DimersBOT, and the best odds available.

And while the Cardinals are more likely to win the game, according to DimersBOT, taking the Reds moneyline is the best option due to the edge identified when comparing our data-led probabilities to the betting odds currently on offer.

Taking advantage of the edges published here at Dimers is crucial to being a profitable sports bettor in the long run.

Reds vs. Cardinals Probabilities

Click or tap on See Matchup for more.

Dimers has full coverage of Friday's Reds-Cardinals matchup, including pregame predictions, best betting picks, and live win probabilities.

Don't forget, DimersBOT updates often, so check this article for any changes to our betting analysis ahead of Reds vs. Cardinals on Friday September 16, 2022.

Reds vs. Cardinals 2022 Game Info

Friday's game between the Cardinals and Reds at Busch Stadium is scheduled to commence at 8:15PM ET.

• Who: Cincinnati Reds vs. St. Louis Cardinals
• Date: Friday September 16, 2022
• Time: 8:15PM ET / 5:15PM PT
• Venue: Busch Stadium

Looking to join an online sportsbook and start betting on MLB? We've reviewed the best available sign-up offers in every legal betting state.

What MLB games are on today?

Now you've got the 411 on Reds vs. Cardinals, check out the latest betting predictions for all upcoming MLB games in our MLB Bet Hub. There you can find probabilities and odds, and our best bets for each and every MLB matchup.

Want a pick for the Run Line? You got it. How about the Over/Under? Yup, got that too. The Moneyline? Yes sir. And these picks are good, I mean REALLY good. Take a look now!

Lastly, Dimers' MLB Futures page is our in-house approach to determining who will win the 2022 World Series, with our data-led probabilities matched against the best odds to win the World Series.