Reds vs. Blue Jays Prediction and Odds - May 21, 2022

The Toronto Blue Jays take on the Cincinnati Reds at Rogers Centre on Saturday, beginning at 3:07PM ET.

The Blue Jays will send Alek Manoah (4-1, 1.71 ERA) to the mound, pitting him against Hunter Greene (1-6, 6.21 ERA) for the Reds.

Dimers' best betting picks for Reds vs. Blue Jays, plus game predictions and best odds, are featured in this article.

Today's Cincinnati vs. Toronto betting preview is proudly sponsored by PointsBet, which has a 5x $100 Risk-Free Bets offer for new customers.

Who will win Reds vs. Blue Jays?

Based on cutting-edge computer power and data, Dimers.com has simulated Saturday's Reds-Blue Jays MLB game 10,000 times.

Dimers' famous predictive analytics model, DimersBOT, currently gives the Blue Jays a 69% chance of beating the Reds .

More: Reds vs. Blue Jays Simulated 10,000 Times

Reds vs. Blue Jays Game Odds

• Run Line: Blue Jays -1.5 (-130), Reds +1.5 (+115)
• Moneyline: Blue Jays -250, Reds +220
• Total: Over/Under 8 (-110/-105)

Run Line, Moneyline and Over/Under

The Blue Jays are -1.5 favorites versus the Reds, with -130 at Caesars Sportsbook the best odds currently available.

For the underdog Reds (+1.5) to cover the run line, FanDuel Sportsbook has the best odds currently on offer at +115.

DraftKings Sportsbook currently has the best moneyline odds for the Blue Jays at -250, which means you can risk $250 to win $100, for a total payout of $350, if they get the W.

Meanwhile, BetMGM currently has the best moneyline odds for the Reds at +220, where you can bet $100 to profit $220, earning a total payout of $320, if they win.

The Over/Under for total runs scored is set at 8 with DraftKings Sportsbook, which currently has the best odds for the Over at -110, while PointsBet currently has the best odds for the Under at -105.

As always, check out all the sportsbooks that are available in your state for the best MLB odds and lines.

According to DimersBOT, the Blue Jays (-1.5) are a 51% chance of covering the run line, while the Over/Under total of 8 runs is a 51% chance of going Under.

More: Free Prop Picks

Best Bets for Reds vs. Blue Jays

• Run Line: Reds +1.5 @ +115 via FanDuel Sportsbook (2.4% edge)
• Moneyline: Reds @ +220 via BetMGM
• Total: Under 8 @ -105 via PointsBet (51% probability)

Dimers' best bets are based on complex simulations and wagering intelligence to help you make smarter decisions with the legal sportsbooks in your state.

Even though the Blue Jays are more likely to cover the run line, our best bet of Reds +1.5 is based on the chance of that happening, according to DimersBOT, and the best odds available.

And while the Blue Jays are more likely to win the game, according to DimersBOT, betting on the Reds moneyline is the best option because of the edge identified when comparing our data-led probabilities to the betting odds currently available.

Taking advantage of the edges published here at Dimers is crucial to being a profitable sports bettor in the long run.

Reds vs. Blue Jays Probabilities

Use our dynamic widget below to see up-to-date Moneyline, Over/Under and Run Line probabilities and odds for Cincinnati vs. Toronto, and click or tap on See Matchup to reveal more.

Dimers has full betting coverage of Saturday's Reds-Blue Jays matchup, including pregame predictions, free picks, and live win probabilities.

Don't forget, DimersBOT updates often, so keep an eye on this article for any changes to our betting analysis ahead of Reds vs. Blue Jays on Saturday May 21, 2022.

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Note: when you click or tap on a link on Dimers that leads to a third-party website that we have a commercial arrangement with (such as a sportsbook), we may earn a referral fee.

Reds vs. Blue Jays 2022 Game Info

Saturday's matchup between the Blue Jays and Reds at Rogers Centre is scheduled to commence at 3:07PM ET.

• Date: Saturday May 21, 2022
• Time: 3:07PM ET / 12:07PM PT
• Venue: Rogers Centre

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What other MLB games are on today?

The Reds and Blue Jays aren't the only two MLB teams you can bet on today. DimersBOT never stops and we've got picks and top bets for every single MLB matchup in our MLB Bet Hub page.

Not only do we provide with you first-class predictions, but we also have recommended bets for the Run Line, Over/Under and Moneyline. Sound good? Hell yeah it does!

While you're here, Dimers' MLB Futures page is our in-house approach to determining who will win the 2022 World Series, with our data-led probabilities matched against the best odds to win the World Series.