Pirates vs. Cubs Prediction and Odds - May 16, 2022

The Chicago Cubs and Pittsburgh Pirates lock horns in MLB at Wrigley Field on Monday, starting at 7:40PM ET.

Wade Miley (0-0, 9.00 ERA) will start for the Cubs, up against Dillon Peters (3-1, 1.83 ERA) for the Pirates.

Dimers' best betting picks for Pirates vs. Cubs, as well as game predictions and best odds, are detailed in this article.

Today's Pittsburgh vs. CHI Cubs betting preview is sponsored by PointsBet, which has an awesome 5x $100 Risk-Free Bets promo for new users.

Who will win Pirates vs. Cubs?

Using high-tech computer power and data, Dimers.com has simulated Monday's Pirates-Cubs MLB matchup 10,000 times.

Dimers' independent predictive analytics model, DimersBOT, currently gives the Cubs a 59% chance of defeating the Pirates .

More: Pirates vs. Cubs Simulated 10K Times

Pirates vs. Cubs Odds

• Run Line: Cubs -1.5 (+125), Pirates +1.5 (-144)
• Moneyline: Cubs -160, Pirates +150
• Total: Over/Under 9 (+105/-115)

Run Line, Moneyline and Over/Under

The Cubs are -1.5 favorites against the Pirates, with +125 at BetMGM the best odds currently available.

For the underdog Pirates (+1.5) to cover the run line, FanDuel Sportsbook has the best odds currently on offer at -144.

DraftKings Sportsbook currently has the best moneyline odds for the Cubs at -160, which means you can risk $160 to win $100, for a total payout of $260, if they get the W.

Meanwhile, FanDuel Sportsbook currently has the best moneyline odds for the Pirates at +150, where you can bet $100 to profit $150, earning a total payout of $250, if they win.

The Over/Under for total runs scored is set at 9 with BetMGM, which currently has the best odds for the Over at +105, while DraftKings Sportsbook currently has the best odds for the Under at -115.

As always, make sure you check all the online sportsbooks that are available in your state for the best MLB odds and lines.

According to DimersBOT, the Pirates (+1.5) are a 61% chance of covering the run line, while the 9-run Over/Under is a 56% chance of going Under.

More: Free Prop Picks

Best Bets for Pirates vs. Cubs

• Run Line: Pirates +1.5 @ -144 via FanDuel Sportsbook (61% probability)
• Moneyline: Pirates @ +150 via FanDuel Sportsbook (1.2% edge)
• Total: Under 9 @ -115 via DraftKings Sportsbook (56% probability)

Dimers' best bets are based on complex simulations and wagering intelligence to help you make smarter investments with the legal sportsbooks in America.

While the Cubs are more likely to win the game, according to DimersBOT, taking the Pirates moneyline is the best option because of the 1.2% edge identified when comparing our data-led probabilities to the sportsbooks' odds currently available.

Taking advantage of the edges seen on Dimers.com is one of the keys to achieving long-term profitability.

Pirates vs. Cubs Betting Guide

Use our dynamic widget below to see the latest Moneyline, Over/Under and Run Line probabilities and odds for Pittsburgh vs. CHI Cubs, and click or tap on See Matchup for more.

Dimers has full betting coverage of Monday's Pirates-Cubs matchup, including pregame predictions, top betting picks, and live win probabilities.

Remember, DimersBOT updates frequently, so keep an eye on this page for any changes to our betting insights before Pirates vs. Cubs on Monday May 16, 2022.

Best Sportsbook Promo for Pirates vs. Cubs

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Note: when you click or tap on a link on Dimers that leads to a third-party website that we have a commercial arrangement with (such as a sportsbook), we may earn a referral fee.

Pirates vs. Cubs 2022 Game Info

Monday's action between the Cubs and Pirates at Wrigley Field is scheduled to commence at 7:40PM ET.

• Date: Monday May 16, 2022
• Time: 7:40PM ET / 4:40PM PT
• Venue: Wrigley Field

Ready to join an online sportsbook and start betting on MLB? Check out the top sportsbook sign-up offers in your state.

What other MLB games are on today?

Now you've got the 411 on Pirates vs. Cubs, get the latest betting predictions for all upcoming MLB games in Dimers' MLB Bet Hub, where you can find probabilities and odds, and our best bets for every single MLB matchup.

Want a pick for the Run Line? You got it. How about the Over/Under? Yup, got that too. The Moneyline? Yes sir. And these picks are good, I mean REALLY good. Take a look now!

While you're here, Dimers' Baseball Futures page is our in-house approach to revealing who will win the 2022 World Series, with our data-led probabilities paired with the best odds to win the World Series.