Padres vs. Giants Prediction and Odds - May 21, 2022

The San Francisco Giants face the San Diego Padres in MLB action at Oracle Park on Saturday, beginning at 4:05PM ET.

Carlos Rodón (4-2, 3.49 ERA) will be on the bump for the Giants, while the Padres will counter with Joe Musgrove (4-0, 2.20 ERA).

Dimers' free betting picks for Padres vs. Giants, as well as game predictions and best odds, are featured below.

Today's San Diego vs. San Francisco betting analysis is proudly sponsored by PointsBet, which has a 5x $100 Risk-Free Bets promo for new customers.

Who will win Padres vs. Giants?

Based on state-of-the-art computer power and data, Dimers.com has simulated Saturday's Padres-Giants MLB matchup 10,000 times.

Dimers' renowned predictive analytics model, DimersBOT, currently gives the Giants a 59% chance of beating the Padres .

More: Padres vs. Giants Simulated 10K Times

Padres vs. Giants Current Odds

• Run Line: Giants -1.5 (+150), Padres +1.5 (-169)
• Moneyline: Giants -150, Padres +140
• Total: Over/Under 7 (+105/-120)

Run Line, Moneyline and Over/Under

The Giants are listed as -1.5 favorites versus the Padres, with +150 at DraftKings Sportsbook the best odds currently available.

For the underdog Padres (+1.5) to cover the run line, Caesars Sportsbook has the best odds currently on offer at -169.

BetMGM currently has the best moneyline odds for the Giants at -150, which means you can risk $150 to win $100, for a total payout of $250, if they get the W.

Meanwhile, Caesars Sportsbook currently has the best moneyline odds for the Padres at +140, where you can bet $100 to profit $140, earning a total payout of $240, if they win.

The Over/Under for total runs scored is set at 7 with DraftKings Sportsbook, which currently has the best odds for the Over at +105, while BetMGM currently has the best odds for the Under at -120.

As always, make sure you check all the sportsbooks available in your state for the best MLB odds and lines.

According to DimersBOT, the Padres (+1.5) are a 62% chance of covering the run line, while the 7-run Over/Under is a 51% chance of going Over.

More: Free Prop Picks

Best Bets for Padres vs. Giants

• Run Line: Padres +1.5 @ -169 via Caesars Sportsbook (62% probability)
• Moneyline: Padres @ +140 via Caesars Sportsbook
• Total: Over 7 @ +105 via DraftKings Sportsbook (51% probability)

Dimers' best bets are based on complex simulations and wagering intelligence to serve you the best possible plays 24/7/365.

While the Giants are more likely to win the game, according to DimersBOT, betting on the Padres moneyline is the best option because of the edge identified when comparing our data-led probabilities to the betting odds currently on offer.

Taking advantage of the edges seen on Dimers.com is pivotal to being a profitable sports bettor in the long run.

Padres vs. Giants Probabilities

Use our interactive widget below to view the latest Moneyline, Over/Under and Run Line probabilities and odds for San Diego vs. San Francisco, and click or tap on See Matchup for more.

Dimers has full betting coverage of Saturday's Padres-Giants matchup, including pregame predictions, best betting picks, and live win probabilities.

Don't forget, DimersBOT updates frequently, so keep an eye on this article for any changes to our betting analysis ahead of Padres vs. Giants on Saturday May 21, 2022.

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Padres vs. Giants 2022 Game Info

Saturday's matchup between the Giants and Padres at Oracle Park is scheduled to start at 4:05PM ET.

• Date: Saturday May 21, 2022
• Time: 4:05PM ET / 1:05PM PT
• Venue: Oracle Park

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Want more MLB analysis like this?

So, you liked our Padres vs. Giants betting analysis? Awesome. Did you know our MLB Betting News page has a detailed betting preview for every MLB matchup as soon as the sportsbooks release their odds?

That's right, our predictive analytics model then compares those odds (aka Vegas odds) against its own probabilities to find value in the markets, which allows us to create the most authoritative MLB betting previews and beat the public and the sportsbooks to the punch.

It's only a click away, so why not take a look around?

Lastly, Dimers' MLB Futures page is our in-house approach to determining who will win the 2022 World Series, with our data-led probabilities matched against the best odds to win the World Series.