Padres vs. Cubs Prediction and Odds - Jun 16, 2022

The Chicago Cubs and San Diego Padres lock horns in MLB at Wrigley Field on Thursday, starting at 2:20PM ET.

The Cubs will have Matt Swarmer (1-1, 4.24 ERA) start, while the Padres are going with Joe Musgrove (7-0, 1.50 ERA).

Dimers' top betting picks for Padres vs. Cubs, as well as game predictions and best odds, are featured below.

Who will win Padres vs. Cubs?

Based on high-tech computer power and data, Dimers.com has simulated Thursday's Padres-Cubs MLB matchup 10,000 times.

Dimers' leading predictive analytics model, DimersBOT, gives the Padres a 61% chance of winning against the Cubs.

More: Free Betting Guide for Padres vs. Cubs

Padres vs. Cubs Game Odds

• Run Line: Cubs +1.5 (+115), Padres -1.5 (-126)
• Moneyline: Cubs +165, Padres -180
• Total: Over/Under 11 (-105/-104)

Run Line, Moneyline and Over/Under

The Cubs are +1.5 underdogs against the Padres, with +115 at DraftKings Sportsbook the best odds currently available.

For the favored Padres (-1.5) to cover the run line, FanDuel Sportsbook has the best odds currently on the market at -126.

Caesars Sportsbook currently has the best moneyline odds for the Cubs at +165. That means you can bet $100 to profit $165, earning a total payout of $265, if they win.

Elsewhere, DraftKings Sportsbook currently has the best moneyline odds for the Padres at -180, where you can risk $180 to win $100, for a total payout of $280, if they come out on top.

The Over/Under sits at 11 with DraftKings Sportsbook, which currently has the best odds for the Over at -105, while FanDuel Sportsbook currently has the best odds for the Under at -104.

As always, make sure you check the sportsbooks you can bet with in your state for the best MLB odds and lines.

According to DimersBOT, the bookmakers have got it right and both the Padres and Cubs are a 50% chance of covering the run line, while the Over/Under total of 11 runs is a 55% chance of going Under.

More: Free Prop Picks

Best Bets for Padres vs. Cubs

• Run Line: Cubs +1.5 @ +115 via DraftKings Sportsbook (50% probability)
• Moneyline: Cubs @ +165 via Caesars Sportsbook (1.8% edge)
• Total: Under 11 @ -104 via FanDuel Sportsbook (55% probability)

Our best bets are based on detailed modeling and betting expertise to help you make smarter decisions with your state's legal sportsbooks.

While the Padres are more likely to win the game, according to DimersBOT, taking the Cubs moneyline is the best option because of the 1.8% edge found when comparing our data-led probabilities to the betting odds currently on offer.

Taking advantage of the edges published here at Dimers.com is one of the keys to achieving long-term profitability as a bettor.

Padres vs. Cubs Prediction

Use our dynamic widget below to explore up-to-date Moneyline, Over/Under and Run Line probabilities and odds for San Diego vs. CHI Cubs, and click or tap on See Matchup to reveal more.

Dimers has full coverage of Thursday's Padres-Cubs matchup, including pregame predictions, top betting picks, and live win probabilities.

Don't forget, DimersBOT updates regularly, so keep checking this page for any changes to our betting insights before Padres vs. Cubs on Thursday June 16, 2022.

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Padres vs. Cubs 2022 Game Info

Thursday's action between the Cubs and Padres at Wrigley Field is scheduled to start at 2:20PM ET.

• Who: Chicago Cubs vs. San Diego Padres
• Date: Thursday June 16, 2022
• Time: 2:20PM ET / 11:20AM PT
• Venue: Wrigley Field

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Want more MLB previews like this?

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Lastly, Dimers' MLB Futures page is our in-house approach to determining who will win the 2022 World Series, with our data-led probabilities paired with the best odds to win the World Series.