MLB picks today: Friday's MLB best bets include Rockies vs. Diamondbacks play [5/22/2026]

Rockies vs. Diamondbacks over 8.5 runs (-121)

• Edge: 7.6%
• Probability: 62.3%
• Matchup: Rockies vs. Diamondbacks (9:40PM ET, Friday)

Our model has identified value on over 8.5 runs in Rockies vs. Diamondbacks at -121 odds. A 62.3% probability produces an edge of 7.6%, making this the strongest play for today's MLB slate.

Twins vs. Red Sox over 7.5 runs (+106)

• Edge: 7.1%
• Probability: 55.6%
• Matchup: Twins vs. Red Sox (7:10PM ET, Friday)

Twins vs. Red Sox over 7.5 runs carries a 7.1% edge and a probability of 55.6% at +106 odds, according to our model.

White Sox vs. Giants over 7.5 runs (+113)

• Edge: 5.0%
• Probability: 52%
• Matchup: White Sox vs. Giants (10:15PM ET, Friday)

White Sox vs. Giants over 7.5 runs at +113 odds shows a 5.0% edge, supported by a 52% probability in simulations.

Nationals vs. Braves over 8.5 runs (-111)

• Edge: 5.0%
• Probability: 57.5%
• Matchup: Nationals vs. Braves (7:15PM ET, Friday)

A 5.0% edge and 57.5% probability make Nationals vs. Braves over 8.5 runs at a value play in the Nationals vs. Braves matchup, per our model.

Athletics vs. Padres over 7.5 runs (-108)

• Edge: 4.7%
• Probability: 56.7%
• Matchup: Athletics vs. Padres (9:40PM ET, Friday)

Athletics vs. Padres over 7.5 runs at -108 odds presents a 4.7% edge, with simulations resulting in a probability of 56.7%.

Dodgers vs. Brewers over 8.5 runs (+106)

• Edge: 4.3%
• Probability: 52.8%
• Matchup: Dodgers vs. Brewers (7:40PM ET, Friday)

Our model finds value on over 8.5 runs in Dodgers vs. Brewers at +106 odds, supported by an edge of 4.3%.

Mets vs. Marlins over 7.5 runs (-116)

• Edge: 3.9%
• Probability: 57.6%
• Matchup: Mets vs. Marlins (7:10PM ET, Friday)

Our model has uncovered value on Mets vs. Marlins over 7.5 runs at -116 odds. A 57.6% probability produces a 3.9% edge, making this a strong play for today's MLB action.

Yankees -1.5 (+160)

• Edge: 3.8%
• Probability: 42.3%
• Matchup: Rays vs. Yankees (7:05PM ET, Friday)

A 3.8% edge on a 42.3% probability makes Yankees -1.5 at +160 odds a solid value play in today's Rays vs. Yankees matchup.

Guardians vs. Phillies over 6.5 runs (-102)

• Edge: 3.8%
• Probability: 54.3%
• Matchup: Guardians vs. Phillies (6:40PM ET, Friday)

Our model projects value on over 6.5 runs at -102 odds. A 54.3% probability produces a 3.8% edge, making the over the favorable side in Saturday’s matchup.

Rays vs. Yankees over 7.5 runs (-111)

• Edge: 3.3%
• Probability: 55.8%
• Matchup: Rays vs. Yankees (7:05PM ET, Friday)

Rounding out our top 10 bets, Rays vs. Yankees over 7.5 runs at -111 odds shows a 55.8% probability and a 3.3% edge.

MLB best bets summary: Friday, 5/22/2026

As of 2:36PM ET, here are our top MLB bets by edge recommended by our model:

List of upcoming MLB games to bet on [5/22/2026]

• Guardians vs. Phillies (6:40PM ET, Friday)
• Cardinals vs. Reds (6:40PM ET, Friday)
• Rays vs. Yankees (7:05PM ET, Friday)
• Pirates vs. Blue Jays (7:07PM ET, Friday)
• Mets vs. Marlins (7:10PM ET, Friday)
• Twins vs. Red Sox (7:10PM ET, Friday)
• Tigers vs. Orioles (7:15PM ET, Friday)
• Nationals vs. Braves (7:15PM ET, Friday)
• Dodgers vs. Brewers (7:40PM ET, Friday)
• Mariners vs. Royals (7:40PM ET, Friday)
• Rangers vs. Angels (9:38PM ET, Friday)
• Rockies vs. D-Backs (9:40PM ET, Friday)
• Athletics vs. Padres (9:40PM ET, Friday)
• White Sox vs. Giants (10:15PM ET, Friday)

Conclusion

Our MLB best bets are locked and loaded for May 22, 2026, featuring plays such as over 8.5 runs in the Rockies vs. Diamondbacks matchup and over 7.5 runs in the Twins vs. Red Sox matchup. Powered by advanced simulations, these picks are here to boost your betting game.

Our predictions are rooted in current data to help you make informed decisions. For additional resources and advice, head to our Responsible Gambling hub.

All odds and probabilities in this article are correct and accurate at the time of publication.