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Read Article Twins vs. White Sox prediction: Why Minnesota is favored to win Monday's MLB matchup [5/25/2026]
Updated: | First published:
Written by Jason Bevilacqua, Head of Content and Communities
Get Minnesota Twins vs Chicago White Sox predictions for MLB Monday.
The Chicago White Sox and Minnesota Twins will meet in MLB action at Rate Field on Monday, starting at 2:10 PM ET.
Anthony Kay (3-1, 4.27 ERA) will get the ball for the White Sox, pitting him against Zebby Matthews (1-1, 1.38 ERA) for the Twins.
Based on the latest simulations, Dimers' advanced MLB model gives the Twins a slight edge with a 51% win probability over the White Sox.
This article offers an expanded analysis of Monday's Twins vs. White Sox matchup, including best bets and picks.
Twins vs. White Sox prediction: Who will win and cover?
Using powerful machine learning and statistical analysis, we have simulated the result of Monday's MLB game between the Twins and White Sox, forming part of our MLB predictions coverage.
Our famous predictive model gives the Twins a 51% chance of defeating the White Sox.
According to our model, the White Sox (+1.5) have a 60% chance of covering the run line, while the 8.5-run over/under has a 54% chance of going over.
Twins vs. White Sox odds [5/25/2026]
We have sourced the best MLB odds in America for this game, which are listed here:
| Bet Type | Twins | White Sox |
|---|---|---|
| Run Line | -1.5 (+153) | +1.5 (-184) |
| Moneyline | -107 | -106 |
| Total | o8.5 (-102) | u8.5 (-120) |
All odds are correct at the time of publication and are subject to change.
Twins vs. White Sox picks and best bet
After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Run Line | Twins -1.5 | +153 |
| Moneyline | Twins | -107 |
| Total | Over 8.5 | -102 |
According to our MLB best bets, the top play to make on this game is Over 8.5 total runs.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Twins vs. White Sox game-day updates and essential details
Monday's MLB action between the White Sox and Twins at Rate Field is scheduled to commence at 2:10 PM ET.
- Who: Minnesota Twins vs. Chicago White Sox
- Date: Monday, May 25, 2026
- Time: 2:10 PM ET/11:10AM PT
- Venue: Rate Field
Conclusion
We predict the Twins, with a 51% win probability, will likely beat the White Sox in Monday's MLB matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
Jason Bevilacqua, an expert in MLB, NHL, NBA, MLS, and NFL, delivers game previews, best bets, and props. Since 2020, as Head of Social and Community at Dimers, he has contributed insightful articles utilizing data-driven models and simulations.
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