Mariners vs. Red Sox Prediction and Odds - May 21, 2022

The Boston Red Sox and Seattle Mariners meet in MLB at Fenway Park on Saturday, starting at 4:10PM ET.

Garrett Whitlock (1-1, 2.43 ERA) will start on the mound for the Red Sox, while the Mariners will counter with Chris Flexen (1-6, 4.35 ERA).

Dimers' free betting picks for Mariners vs. Red Sox, plus game predictions and best odds, are detailed in this article.

Today's Seattle vs. Boston betting analysis is proudly sponsored by PointsBet, which has a tasty 5x $100 Risk-Free Bets promo for new users.

Who will win Mariners vs. Red Sox?

Based on advanced machine learning and data, Dimers.com has simulated Saturday's Mariners-Red Sox MLB game 10,000 times.

Dimers' proven predictive analytics model, DimersBOT, gives the Red Sox a 58% chance of winning against the Mariners .

More: Free Betting Guide for Mariners vs. Red Sox

Mariners vs. Red Sox Odds

• Run Line: Red Sox -1.5 (+125), Mariners +1.5 (-134)
• Moneyline: Red Sox -154, Mariners +142
• Total: Over/Under 9 (-115/+105)

Run Line, Moneyline and Over/Under

The Red Sox are -1.5 favorites versus the Mariners, with +125 at BetMGM the best odds currently available.

For the underdog Mariners (+1.5) to cover the run line, FanDuel Sportsbook has the best odds currently on offer at -134.

Caesars Sportsbook currently has the best moneyline odds for the Red Sox at -154. That means you can risk $154 to win $100, for a total payout of $254, if they get the W.

Meanwhile, FanDuel Sportsbook currently has the best moneyline odds for the Mariners at +142, where you can bet $100 to profit $142, earning a total payout of $242, if they win.

The Over/Under for total runs scored is set at 9 with BetMGM, which currently has the best odds for the Over at -115, while Caesars Sportsbook currently has the best odds for the Under at +105.

As always, make sure you check the sportsbooks you have access to in your state for the best MLB odds and lines.

According to DimersBOT, the Mariners (+1.5) are a 56% chance of covering the run line, while the Over/Under total of 9 runs is considered an equal 50-50 chance of hitting.

More: Best Prop Bets to Make Today

Best Bets for Mariners vs. Red Sox

• Run Line: Red Sox -1.5 @ +125 via BetMGM
• Moneyline: Mariners @ +142 via FanDuel Sportsbook (0.5% edge)
• Total: Under 9 @ +105 via Caesars Sportsbook (50% probability)

Dimers' best bets are based on detailed simulations and betting intelligence to help you make more informed investments with the legal sportsbooks in America.

Even though the Mariners are more likely to cover the run line, our best bet of Red Sox -1.5 is based on the chance of that happening, according to DimersBOT, and the best odds available.

And while the Red Sox are more likely to win the game, according to DimersBOT, betting on the Mariners moneyline is the best option because of the edge identified when comparing our data-led probabilities to the sportsbooks' odds currently available.

Taking advantage of the edges seen here at Dimers is one of the keys to achieving long-term profitability as a sports bettor.

Mariners vs. Red Sox Probabilities

Use our interactive widget below to see up-to-date Moneyline, Over/Under and Run Line probabilities and odds for Seattle vs. Boston, and click or tap on See Matchup to reveal more.

Dimers has full coverage of Saturday's Mariners-Red Sox matchup, including pregame predictions, free picks, and live updates.

Remember, DimersBOT updates frequently, so keep checking this article for the latest betting insights ahead of Mariners vs. Red Sox on Saturday May 21, 2022.

Risk-Free Bet for Mariners vs. Red Sox

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Note: when you click or tap on a link on Dimers that leads to a third-party website that we have a commercial arrangement with (such as a sportsbook), we may earn a referral fee.

Mariners vs. Red Sox 2022 Game Info

Saturday's matchup between the Red Sox and Mariners at Fenway Park is scheduled to commence at 4:10PM ET.

• Date: Saturday May 21, 2022
• Time: 4:10PM ET / 1:10PM PT
• Venue: Fenway Park

Looking to join an online sportsbook and start betting on MLB? Check out the top sports betting promos in your state.

What other MLB games are on today?

The Mariners and Red Sox aren't the only two MLB teams you can bet on. DimersBOT never stops and we've got picks and top bets for every single MLB game in our MLB Bet Hub page.

Not only do we provide with you first-class predictions, but we also have recommended bets for the Run Line, Over/Under and Moneyline. Sound good? Check it out today!

Lastly, Dimers' Baseball Futures page is our in-house approach to determining who will win the 2022 World Series, with our data-led probabilities paired with the best odds to win the World Series.