Louisiana-Lafayette vs. Old Dominion prediction: Old Dominion favored to win men's college basketball matchup [2/16/2026]

Old Dominion will square off with Louisiana-Lafayette in men's college basketball action at Chartway Arena on Monday, starting at 5:00 PM ET.

Based on the latest simulations, Dimers' advanced college basketball model predicts Old Dominion as the most likely winner of the Louisiana-Lafayette vs. Old Dominion game.

This article offers further insights into Monday's matchup, including an expanded look at the predicted score, best bets and picks.

Louisiana-Lafayette vs. Old Dominion prediction: Who will win and cover?

Using powerful machine learning and data, we have simulated the outcome of Monday's NCAA basketball game between Louisiana-Lafayette and Old Dominion 10,000 times as part of our men's college basketball predictions coverage.

Our famous predictive model currently gives Old Dominion a 69% chance of beating Louisiana-Lafayette. Our predicted final score has Old Dominion winning 72-67.

According to our model, Louisiana-Lafayette (+5.5) has a 55% chance of covering the spread, while the 136.5-point over/under has a 55% chance of going over.

Louisiana-Lafayette vs. Old Dominion odds

We have researched the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Louisiana-Lafayette vs. Old Dominion picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: