Guardians vs. Twins Prediction and Odds - Jun 21, 2022

MLB action continues on Tuesday at 7:40PM ET as the Cleveland Guardians take on the Minnesota Twins at Target Field.

The Twins will send Joe Ryan (5-3, 2.81 ERA) to the mound, pitting him against Aaron Civale (2-3, 7.84 ERA) for the Guardians.

Dimers' top betting picks for Guardians vs. Twins, as well as game predictions and betting odds, are featured below.

Who will win Guardians vs. Twins?

Based on state-of-the-art computer power and data, Dimers.com has simulated Tuesday's Guardians-Twins MLB matchup 10,000 times.

Dimers' revolutionary predictive analytics model, DimersBOT, currently gives the Twins a 58% chance of beating the Guardians.

More: Guardians vs. Twins Simulated 10,000 Times

Guardians vs. Twins Odds

• Run Line: Twins -1.5 (+120), Guardians +1.5 (-135)
• Moneyline: Twins -161, Guardians +145
• Total: Over/Under 9.5 (+105/-115)

Run Line, Moneyline and Over/Under

The Twins are listed as -1.5 favorites against the Guardians, with +120 at DraftKings Sportsbook the best odds currently available.

For the underdog Guardians (+1.5) to cover the run line, BetMGM has the best odds currently on offer at -135.

Caesars Sportsbook currently has the best moneyline odds for the Twins at -161. That means you can risk $161 to win $100, for a total payout of $261, if they get the W.

Elsewhere, BetMGM currently has the best moneyline odds for the Guardians at +145, where you can put down $100 to profit $145, earning a total payout of $245, if they win.

The Over/Under for total runs scored is set at 9.5 with DraftKings Sportsbook, which currently has the best odds for the Over at +105, while Caesars Sportsbook currently has the best odds for the Under at -115.

As always, check out the sportsbooks you can bet with in your state for the best MLB odds and lines.

According to DimersBOT, the Guardians (+1.5) are a 56% chance of covering the run line, while the Over/Under total of 9.5 runs is a 52% chance of going Under.

More: Best Prop Bets Today

Best Bets for Guardians vs. Twins

• Run Line: Guardians +1.5 @ -135 via BetMGM (56% probability)
• Moneyline: Guardians @ +145 via BetMGM (1.1% edge)
• Total: Over 9.5 @ +105 via DraftKings Sportsbook

Dimers' best bets are based on detailed modeling and betting expertise to bring you the best possible plays 24/7/365.

While the Twins are more likely to win the game, according to DimersBOT, taking the Guardians moneyline is the best option because of the 1.1% edge identified when comparing our data-led probabilities to the betting odds currently available.

Taking advantage of the edges seen on Dimers.com is crucial to achieving long-term profitability as a sports bettor.

Furthermore, despite the Under being more likely to hit on this occasion, Over 9.5 is our best bet owing to the better odds (+105) that are available from DraftKings Sportsbook.

Guardians vs. Twins Prediction

Use our interactive widget below to explore up-to-date Moneyline, Over/Under and Run Line probabilities and odds for Cleveland vs. Minnesota, and click or tap on See Matchup to reveal more.

Dimers has full coverage of Tuesday's Guardians-Twins matchup, including pregame predictions, free betting picks, and live win probabilities.

Don't forget, DimersBOT updates regularly, so keep checking this page for any changes to our betting analysis ahead of Guardians vs. Twins on Tuesday June 21, 2022.

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Guardians vs. Twins 2022 Game Info

Tuesday's matchup between the Twins and Guardians at Target Field is scheduled to start at 7:40PM ET.

• Who: Minnesota Twins vs. Cleveland Guardians
• Date: Tuesday June 21, 2022
• Time: 7:40PM ET / 4:40PM PT
• Venue: Target Field

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