Guardians vs. Tigers Prediction and Odds - May 28, 2022

The Detroit Tigers and Cleveland Guardians lock horns in MLB at Comerica Park on Saturday, starting at 4:10PM ET.

Alex Faedo (1-1, 3.00 ERA) will be on the bump for the Tigers, pitting him against Shane Bieber (1-3, 3.55 ERA) for the Guardians.

Dimers' free betting picks for Guardians vs. Tigers, as well as game predictions and best odds, are featured in this article.

This Cleveland vs. Detroit betting analysis is sponsored by PointsBet, which has an awesome 5x $100 Risk-Free Bets promo for new customers.

Who will win Guardians vs. Tigers?

Based on cutting-edge machine learning and data, Dimers.com has simulated Saturday's Guardians-Tigers MLB matchup 10,000 times.

Dimers' leading predictive analytics model, DimersBOT, gives the Guardians a 61% chance of defeating the Tigers.

More: Full Betting Guide for Guardians vs. Tigers

Guardians vs. Tigers Odds

• Run Line: Tigers +1.5 (-125), Guardians -1.5 (+110)
• Moneyline: Tigers +145, Guardians -161
• Total: Over/Under 7 (-120/+105)

Run Line, Moneyline and Over/Under

The Tigers are listed as +1.5 underdogs against the Guardians, with -125 at DraftKings Sportsbook the best odds currently available.

For the favored Guardians (-1.5) to cover the run line, Caesars Sportsbook has the best odds currently on offer at +110.

DraftKings Sportsbook currently has the best moneyline odds for the Tigers at +145. That means you can throw down $100 to profit $145, earning a total payout of $245, if they win.

On the other hand, Caesars Sportsbook currently has the best moneyline odds for the Guardians at -161, where you can risk $161 to win $100, for a total payout of $261, if they come out on top.

The Over/Under for total runs scored sits at 7 with BetMGM, which currently has the best odds for the Over at -120, while PointsBet currently has the best odds for the Under at +105.

As always, make sure you check all the legal sportbooks available in your state for the best MLB odds and lines.

According to DimersBOT, the Tigers (+1.5) are a 54% chance of covering the run line, while the Over/Under total of 7 runs is a 56% chance of going Over.

More: Best Prop Bets Today

Best Bets for Guardians vs. Tigers

• Run Line: Guardians -1.5 @ +110 via Caesars Sportsbook
• Moneyline: Guardians @ -161 via Caesars Sportsbook (61% probability)
• Total: Over 7 @ -120 via BetMGM (56% probability)

Dimers' best bets are based on complex simulations and wagering intelligence to bring you the best possible plays every time.

Although the Tigers are more likely to cover the run line, our best bet of Guardians -1.5 is based on the chance of that happening, according to DimersBOT, and the best odds available.

Guardians vs. Tigers Probabilities

Use our interactive widget below to see the latest Moneyline, Over/Under and Run Line probabilities and odds for Cleveland vs. Detroit, and click or tap on See Matchup for more.

Dimers has full coverage of Saturday's Guardians-Tigers matchup, including pregame predictions, top betting picks, and live win probabilities.

Remember, DimersBOT updates often, so keep an eye on this page for the latest betting analysis ahead of Guardians vs. Tigers on Saturday May 28, 2022.

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Note: when you click or tap on a link on Dimers that leads to a third-party website that we have a commercial arrangement with (such as a sportsbook), we may earn a referral fee.

Guardians vs. Tigers 2022 Game Info

Saturday's game between the Tigers and Guardians at Comerica Park is scheduled to begin at 4:10PM ET.

• Who: Detroit Tigers vs. Cleveland Guardians
• Date: Saturday May 28, 2022
• Time: 4:10PM ET / 1:10PM PT
• Venue: Comerica Park

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What MLB games are on today?

Now you've got the 411 on Guardians vs. Tigers, take a look at the latest betting coverage for all upcoming MLB games in our MLB Bet Hub, where you can find probabilities and odds, as well as our best bets for each and every MLB matchup.

Want a pick for the Run Line? You got it. How about the Over/Under? Yup, got that too. The Moneyline? Yes sir. And these picks are good, I mean REALLY good. Take a look now!

Finally, Dimers' Baseball Futures page is our in-house approach to revealing who will win the 2022 World Series, with our data-led probabilities paired with the best odds to win the World Series.