Guardians vs. Astros Prediction and Odds - May 25, 2022

The Houston Astros face the Cleveland Guardians in MLB action at Minute Maid Park on Wednesday, commencing at 8:10PM ET.

Cristian Javier (2-2, 2.87 ERA) will start for the Astros, while the Guardians will counter with Cal Quantrill (1-2, 3.48 ERA).

Dimers' free betting picks for Guardians vs. Astros, plus game predictions and best odds, are featured in this article.

Today's Cleveland vs. Houston betting analysis is proudly sponsored by PointsBet, which has an awesome 5x $100 Risk-Free Bets promo for new users.

Who will win Guardians vs. Astros?

Using trusted machine learning and data, Dimers.com has simulated Wednesday's Guardians-Astros MLB game 10,000 times.

Dimers' proven predictive analytics model, DimersBOT, currently gives the Astros a 61% chance of defeating the Guardians.

More: Guardians vs. Astros Simulated 10,000 Times

Guardians vs. Astros Game Odds

• Run Line: Astros -1.5 (+110), Guardians +1.5 (-120)
• Moneyline: Astros -185, Guardians +165
• Total: Over/Under 8 (-110/-110)

Run Line, Moneyline and Over/Under

The Astros are currently -1.5 favorites against the Guardians, with +110 at DraftKings Sportsbook the best odds currently available.

For the underdog Guardians (+1.5) to cover the run line, FanDuel Sportsbook has the best odds currently on offer at -120.

Caesars Sportsbook currently has the best moneyline odds for the Astros at -185, which means you can risk $185 to win $100, for a total payout of $285, if they get the W.

On the other hand, Caesars Sportsbook also has the best moneyline odds for the Guardians at +165, where you can bet $100 to profit $165, earning a total payout of $265, if they win.

The Over/Under for total runs scored is set at 8 with DraftKings Sportsbook, which currently has the best odds for the Over at -110, as well as the best odds for the Under at -110.

As always, make sure you check the sportsbooks you can bet with in your state for the best MLB odds and lines.

According to DimersBOT, the Guardians (+1.5) are a 56% chance of covering the run line, while the Over/Under total of 8 runs is a 56% chance of going Over.

More: Best Prop Bets to Make Today

Best Bets for Guardians vs. Astros

• Run Line: Guardians +1.5 @ -120 via FanDuel Sportsbook (56% probability)
• Moneyline: Guardians @ +165 via Caesars Sportsbook (1.1% edge)
• Total: Over 8 @ -110 via DraftKings Sportsbook (56% probability)

Dimers' best bets are based on world-class simulations and betting intelligence to help you make smarter decisions with the legal sportsbooks in America.

While the Astros are more likely to win the game, according to DimersBOT, taking the Guardians moneyline is the best option due to the 1.1% edge identified when comparing our data-led probabilities to the betting odds currently on offer.

Taking advantage of the edges seen here at Dimers.com is pivotal to being a profitable bettor in the long run.

Guardians vs. Astros Betting Guide

Use our dynamic widget below to view the latest Moneyline, Over/Under and Run Line probabilities and odds for Cleveland vs. Houston, and click or tap on See Matchup to reveal more.

Dimers has full coverage of Wednesday's Guardians-Astros matchup, including pregame predictions, top betting picks, and live win probabilities.

Don't forget, DimersBOT updates regularly, so check this article for the latest betting analysis ahead of Guardians vs. Astros on Wednesday May 25, 2022.

Best Sportsbook Promo for Guardians vs. Astros

Do you want to bet on Cleveland vs. Houston? Join FanDuel Sportsbook today and get your first bet risk free up to $1,000, which you can use on Wednesday's Guardians-Astros game.

Simply click or tap on this exclusive FanDuel Sportsbook link and create an account – it's easy and takes less than 2 minutes.

Then, make your first deposit and place a bet up to $1,000 on Guardians vs. Astros. If you don't win your bet, FanDuel Sportsbook will refund it in site credit!

This offer is available to all new FanDuel Sportsbook users. How good is that!

Note: when you click or tap on a link on Dimers that leads to a third-party website that we have a commercial arrangement with (such as a sportsbook), we may earn a referral fee.

Guardians vs. Astros 2022 Game Info

Wednesday's game between the Astros and Guardians at Minute Maid Park is scheduled to begin at 8:10PM ET.

• Who: Houston Astros vs. Cleveland Guardians
• Date: Wednesday May 25, 2022
• Time: 8:10PM ET / 5:10PM PT
• Venue: Minute Maid Park

Enjoy Dimers.com and want to keep the site free? Every time you join a sportsbook featured here, we get paid a small fee.

These fees help us keep Dimers free for everyone. So, if you like what you see, support us by joining one of our legal sports betting partners now.

Want more MLB predictions like this?

So, you liked our Guardians vs. Astros betting analysis? Awesome. Did you know our MLB Betting News page has a detailed betting preview for every MLB matchup the second the sportsbooks put out their odds?

That's right, our predictive analytics model then compares those odds against its own probabilities to find edges in the markets. This allows us to create the most accurate MLB betting previews and get the jump on the public and the sportsbooks.

It's only a click away, so why not take a look around?

Lastly, Dimers' Baseball Futures page is our in-house approach to revealing who will win the 2022 World Series, with our data-led probabilities paired with the best odds on the market.