Guardians vs. Astros Prediction and Odds - May 23, 2022

The Houston Astros square off with the Cleveland Guardians in MLB action at Minute Maid Park on Monday, starting at 8:10PM ET.

The Astros will have Luis Garcia (3-2, 3.34 ERA) start, up against Triston McKenzie (2-3, 2.97 ERA) for the Guardians.

Dimers' top betting picks for Guardians vs. Astros, plus game predictions and best odds, are featured below.

This Cleveland vs. Houston betting preview is proudly sponsored by PointsBet, which has a great 5x $100 Risk-Free Bets promo for new users.

Who will win Guardians vs. Astros?

Using cutting-edge machine learning and data, Dimers.com has simulated Monday's Guardians-Astros MLB game 10,000 times.

Dimers' proven predictive analytics model, DimersBOT, currently gives the Astros a 60% chance of defeating the Guardians.

More: Guardians vs. Astros Simulated 10,000 Times

Guardians vs. Astros Odds

• Run Line: Astros -1.5 (+116), Guardians +1.5 (-120)
• Moneyline: Astros -175, Guardians +175
• Total: Over/Under 8 (-105/-112)

Run Line, Moneyline and Over/Under

The Astros are -1.5 favorites against the Guardians, with +116 at FanDuel Sportsbook the best odds currently available.

For the underdog Guardians (+1.5) to cover the run line, PointsBet has the best odds currently on offer at -120.

BetMGM currently has the best moneyline odds for the Astros at -175, which means you can risk $175 to win $100, for a total payout of $275, if they get the W.

Elsewhere, Caesars Sportsbook currently has the best moneyline odds for the Guardians at +175, where you can bet $100 to profit $175, earning a total payout of $275, if they win.

The Over/Under is set at 8 with BetMGM, which currently has the best odds for the Over at -105, while FanDuel Sportsbook currently has the best odds for the Under at -112.

As always, check out all the legal sportbooks that are available in your state for the best MLB odds and lines.

According to DimersBOT, the Guardians (+1.5) are a 59% chance of covering the run line, while the Over/Under total of 8 runs is a 52% chance of going Over.

More: Free Prop Picks

Best Bets for Guardians vs. Astros

• Run Line: Guardians +1.5 @ -120 via PointsBet (59% probability) 🔥
• Moneyline: Guardians @ +175 via Caesars Sportsbook (4.0% edge) 🔥
• Total: Over 8 @ -105 via BetMGM (52% probability)

When you see a 🔥, that means you've found one of our best bets today across all major pro and college sports.

Dimers' best bets are based on complex simulations and wagering intelligence to help you make more informed decisions with the legal sportsbooks in America.

While the Astros are more likely to win the game, according to DimersBOT, betting on the Guardians moneyline is the best option due to the 4.0% edge identified when comparing our data-led probabilities to the sportsbooks' odds currently on offer.

Taking advantage of the edges seen on Dimers is crucial to being profitable in the long run.

Guardians vs. Astros Betting Guide

Use our interactive widget below to view the latest Moneyline, Over/Under and Run Line probabilities and odds for Cleveland vs. Houston, and click or tap on See Matchup to reveal more.

Dimers has full betting coverage of Monday's Guardians-Astros matchup, including pregame predictions, computer picks, and live win probabilities.

Don't forget, DimersBOT updates frequently, so keep an eye on this page for the latest betting insights before Guardians vs. Astros on Monday May 23, 2022.

Best Sportsbook Promo for Guardians vs. Astros

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Note: when you click or tap on a link on Dimers that leads to a third-party website that we have a commercial arrangement with (such as a sportsbook), we may earn a referral fee.

Guardians vs. Astros 2022 Game Info

Monday's matchup between the Astros and Guardians at Minute Maid Park is scheduled to commence at 8:10PM ET.

• Who: Houston Astros vs. Cleveland Guardians
• Date: Monday May 23, 2022
• Time: 8:10PM ET / 5:10PM PT
• Venue: Minute Maid Park

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Lastly, Dimers' Baseball Futures page is our in-house approach to revealing who will win the 2022 World Series, with our data-led probabilities matched against the best odds available.