NFL- More Betting
Giants vs. 49ers Week 3 Prediction and Odds - September 21, 2023

The San Francisco 49ers will square off with the New York Giants in NFL Week 3 action at Levi's Stadium on Thursday, beginning at 8:15PM ET.
Dimers' free betting picks for Giants vs. 49ers, plus game predictions, betting odds and projected player stats, are detailed in this article.
This NY Giants vs. San Francisco betting preview is proudly sponsored by Bet365, which has an awesome Bet $1, Get $365 in Bonus Bets promo for new customers.
Who Will Win: Giants vs. 49ers
Using advanced computer power and data, Dimers.com has simulated Thursday's Giants-49ers NFL game 10,000 times.
Dimers' independent predictive analytics model, DimersBOT, currently gives the 49ers an 83% chance of winning against the Giants in Week 3 of the NFL season.
More: Betting Guide for Giants vs. 49ers
Giants vs. 49ers Odds
- Spread: 49ers -10.5 (-110), Giants +10.5 (-105)
- Moneyline: 49ers -535, Giants +425
- Total: Over/Under 43.5 (-106/-108)
The 49ers are -10.5 favorites versus the Giants, with -110 at PointsBet the best odds currently available.
For the underdog Giants (+10.5) to cover the spread, DraftKings Sportsbook has the best odds currently on offer at -105.
DraftKings Sportsbook currently has the best moneyline odds for the 49ers at -535, which means you can risk $535 to win $100, for a total payout of $635, if they get the W.
Meanwhile, BetMGM currently has the best moneyline odds for the Giants at +425, where you can bet $100 to profit $425, earning a total payout of $525, if they win.
The Over/Under sits at 43.5 with FanDuel Sportsbook, which currently has the best odds for the Over at -106, while DraftKings Sportsbook currently has the best odds for the Under at -108.
As always, make sure you check all the sportsbooks available in your state for the best NFL odds and lines.
According to DimersBOT, the Giants (+10.5) have a 54% chance of covering the spread, while the 43.5-point Over/Under has an equal 50-50 chance of hitting.
More: Best Prop Bets to Make Today
Best Bets: Giants vs. 49ers
- Spread: Giants +10.5 @ -105 via DraftKings Sportsbook (54% probability)
- Moneyline: 49ers @ -535 via DraftKings Sportsbook (83% probability)
- Total: Over 43.5 @ -106 via FanDuel Sportsbook (50% probability)
Our best bets are based on complex simulations and wagering expertise to help you make more informed investments with your state's legal sportsbooks.
Giants vs. 49ers Prediction
Dimers.com's predicted final score for NY Giants vs. San Francisco at Levi's Stadium in Week 3 has the 49ers winning 26-16.
Click or tap on See Matchup to find out more.
Dimers has full coverage of this week's Giants-49ers game in Week 3, including pregame predictions, best betting picks, and live updates.
Giants vs. 49ers Player Props
Who will score the first touchdown in Giants vs. 49ers? The data is in.
Listed below are the most likely first touchdown and most likely anytime touchdown scorers for both the Giants and 49ers, as well as player stat projections.
And you know what, we provide this information to you for FREE to help you choose the best prop picks for Thursday's game.
According to DimersBOT, San Francisco's Christian McCaffrey is most likely to score the first TD in Giants vs. 49ers.
DimersBOT gives McCaffrey a 21.3% chance of getting in for six first at Levi's Stadium, while the 49ers RB is a 69.8% chance of registering an anytime touchdown.
Scroll down for our full list of first and anytime TD scorer probabilities, which provide a great avenue for you to use this DraftKings Sportsbook offer, which unlocks $200 in bonus bets from a $5 bet on any of the below players.
First Touchdown Scorer Probabilities
New York Giants
- Matt Breida: 6.1% probability
- Daniel Jones: 5.7% probability
- Darren Waller: 5.4% probability
- Darius Slayton: 4.6% probability
- Parris Campbell: 3.5% probability
San Francisco 49ers
- Christian McCaffrey: 21.3% probability
- Deebo Samuel: 12.8% probability
- George Kittle: 9.6% probability
- Jauan Jennings: 4.3% probability
- Elijah Mitchell: 4.2% probability
Anytime Touchdown Scorer Probabilities
New York Giants
- Matt Breida: 27.2% probability
- Daniel Jones: 25.5% probability
- Darren Waller: 25.4% probability
- Darius Slayton: 20.9% probability
- Parris Campbell: 17.0% probability
San Francisco 49ers
- Christian McCaffrey: 69.8% probability
- Deebo Samuel: 51.4% probability
- George Kittle: 38.8% probability
- Jauan Jennings: 20.4% probability
- Elijah Mitchell: 19.0% probability
Giants-49ers Projected Player Stats
Of the starting quarterbacks, the Giants' Daniel Jones is projected for 204 passing yards, while the 49ers' Brock Purdy is expected to throw for 229 yards.
Giants Starting QB
- Daniel Jones: 204 projected yards
49ers Starting QB
- Brock Purdy: 229 projected yards
Giants Rushing
- Matt Breida: 41 projected yards
- Daniel Jones: 33 projected yards
- Gary Brightwell: 22 projected yards
49ers Rushing
- Christian McCaffrey: 92 projected yards
- Elijah Mitchell: 15 projected yards
- Deebo Samuel: 14 projected yards
Giants Receiving
- Darren Waller: 45 projected yards
- Darius Slayton: 40 projected yards
- Parris Campbell: 34 projected yards
- Isaiah Hodgins: 28 projected yards
- Wan'Dale Robinson: 23 projected yards
49ers Receiving
- Deebo Samuel: 71 projected yards
- George Kittle: 55 projected yards
- Jauan Jennings: 33 projected yards
- Christian McCaffrey: 32 projected yards
- Ronnie Bell: 31 projected yards
Don't forget, DimersBOT updates frequently, so refresh this page for any changes to our betting insights ahead of Giants vs. 49ers on Thursday September 21, 2023.
Giants vs. 49ers 2023
The NFL Week 3 action between the 49ers and Giants at Levi's Stadium is scheduled to begin at 8:15PM ET.
- Who: New York Giants vs. San Francisco 49ers
- Date: Thursday September 21, 2023
- Time: 8:15PM ET / 5:15PM PT
- Venue: Levi's Stadium
Enjoy Dimers and want to keep the site free? Every time you sign up and bet with a sportsbook featured here, we get paid a small fee.
These fees help us keep Dimers free for all sports fans. So, if you like what you see, support us by joining one of our trusted sports betting partners, including DraftKings Sportsbook, where you get $200 in bonus bets for signing up and bettting $5 on NY Giants vs. San Francisco.
Make Informed Sports Betting Decisions with Dimers
Dimers' picks are made after 10,000 simulations per game, using reliable and up-to-date data sources and analytical methods.
While these Giants vs. 49ers predictions can help you make informed decisions, it's vital that you gamble responsibly and manage your bankroll effectively.
For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
What Other NFL Games Are on Today?
The Giants and 49ers aren't the only two NFL teams you can bet on. DimersBOT never stops and we've got picks and top bets for each and every NFL matchup via our NFL predictions. Not only do we provide with you great predictions, but we also have recommended bets for the Spread, Over/Under and Moneyline. Sound good? Hell yeah it does!
In addition to our leading NFL predictions, we also feature the best NFL prop bets today, projecting passing yards, touchdowns, and more against the top odds available every day of the NFL season.