D-Backs vs. Cubs Prediction and Odds - May 21, 2022

The Chicago Cubs take on the Arizona D-Backs at Wrigley Field on Saturday, beginning at 2:20PM ET.

The Cubs will send Justin Steele (1-4, 4.50 ERA) to the mound, pitting him against Madison Bumgarner (2-2, 2.29 ERA) for the D-Backs.

Dimers' free betting picks for D-Backs vs. Cubs, plus game predictions and best odds, are detailed below.

This Arizona vs. CHI Cubs betting analysis is brought to you by PointsBet, which has a 5x $100 Risk-Free Bets promo for new users.

Who will win D-Backs vs. Cubs?

Based on trusted computer power and data, Dimers.com has simulated Saturday's D-Backs-Cubs MLB game 10,000 times.

Dimers' leading predictive analytics model, DimersBOT, gives the Cubs a 56% chance of getting the W against the D-Backs .

More: D-Backs vs. Cubs Simulated 10,000 Times

D-Backs vs. Cubs Current Odds

• Run Line: Cubs -1.5 (+155), D-Backs +1.5 (-169)
• Moneyline: Cubs -135, D-Backs +120
• Total: Over/Under 7.5 (+110/-120)

Run Line, Moneyline and Over/Under

The Cubs are -1.5 favorites against the D-Backs, with +155 at BetMGM the best odds currently available.

For the underdog D-Backs (+1.5) to cover the run line, Caesars Sportsbook has the best odds currently on offer at -169.

BetMGM currently has the best moneyline odds for the Cubs at -135. That means you can risk $135 to win $100, for a total payout of $235, if they get the W.

Meanwhile, FanDuel Sportsbook currently has the best moneyline odds for the D-Backs at +120, where you can bet $100 to profit $120, earning a total payout of $220, if they win.

The Over/Under for total runs scored is set at 7.5 with PointsBet, which currently has the best odds for the Over at +110, while Caesars Sportsbook currently has the best odds for the Under at -120.

As always, check out the sportsbooks you can bet with in your state for the best MLB odds and lines.

According to DimersBOT, the D-Backs (+1.5) are a 62% chance of covering the run line, while the Over/Under total of 7.5 runs is a 53% chance of going Over.

More: Free Prop Picks

Best Bets for D-Backs vs. Cubs

• Run Line: D-Backs +1.5 @ -169 via Caesars Sportsbook (62% probability)
• Moneyline: Cubs @ -135 via BetMGM (56% probability)
• Total: Over 7.5 @ +110 via PointsBet (53% probability) 🔥

If you see a 🔥, you know you've found one of Dimers' best free picks of the day across all sports.

Dimers' best bets are based on complex simulations and wagering intelligence to bring you the best possible plays 24/7/365.

D-Backs vs. Cubs Betting Guide

Use our interactive widget below to see up-to-date Moneyline, Over/Under and Run Line probabilities and odds for Arizona vs. CHI Cubs, and click or tap on See Matchup for more.

Dimers has full betting coverage of Saturday's D-Backs-Cubs matchup, including pregame predictions, top betting picks, and live scores.

Remember, DimersBOT updates regularly, so keep checking this page for the latest betting analysis before D-Backs vs. Cubs on Saturday May 21, 2022.

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D-Backs vs. Cubs 2022 Game Info

Saturday's game between the Cubs and D-Backs at Wrigley Field is scheduled to begin at 2:20PM ET.

• Date: Saturday May 21, 2022
• Time: 2:20PM ET / 11:20AM PT
• Venue: Wrigley Field

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Want more MLB predictions like this?

So, you liked our D-Backs vs. Cubs betting analysis? Awesome. Did you know our MLB Betting News section has a detailed betting preview for every MLB game as soon as the sportsbooks release their odds?

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It's only a click away, so why not take a look around?

Lastly, Dimers' Baseball Futures page is our in-house approach to determining who will win the 2022 World Series, with our data-led probabilities matched against the best odds to win the World Series.