D-Backs vs. Cubs Prediction and Odds - May 20, 2022

The Chicago Cubs square off with the Arizona D-Backs at Wrigley Field on Friday, commencing at 2:20PM ET.

The Cubs will have Kyle Hendricks (2-3, 4.03 ERA) start, while the D-Backs will counter with Humberto Castellanos (2-1, 4.15 ERA).

Dimers' top betting picks for D-Backs vs. Cubs, plus game predictions and best odds, are detailed in this article.

This Arizona vs. CHI Cubs betting preview is proudly sponsored by PointsBet, which has an outstanding 5x $100 Risk-Free Bets offer for new users.

Who will win D-Backs vs. Cubs?

Based on advanced machine learning and data, Dimers.com has simulated Friday's D-Backs-Cubs MLB game 10,000 times.

Dimers' popular predictive analytics model, DimersBOT, gives the Cubs a 54% chance of winning against the D-Backs .

More: D-Backs vs. Cubs Simulated 10K Times

D-Backs vs. Cubs Current Odds

• Run Line: Cubs -1.5 (+126), D-Backs +1.5 (-145)
• Moneyline: Cubs -140, D-Backs +125
• Total: Over/Under 11.5 (+100/-115)

Run Line, Moneyline and Over/Under

The Cubs are -1.5 favorites versus the D-Backs, with +126 at FanDuel Sportsbook the best odds currently available.

For the underdog D-Backs (+1.5) to cover the run line, Caesars Sportsbook has the best odds currently on offer at -145.

BetMGM currently has the best moneyline odds for the Cubs at -140. That means you can risk $140 to win $100, for a total payout of $240, if they get the W.

Meanwhile, DraftKings Sportsbook currently has the best moneyline odds for the D-Backs at +125, where you can bet $100 to profit $125, earning a total payout of $225, if they win.

The Over/Under sits at 11.5 with DraftKings Sportsbook, which currently has the best odds for the Over at +100, while Caesars Sportsbook currently has the best odds for the Under at -115.

As always, check out the sportsbooks you can bet with in your state for the best MLB odds and lines.

According to DimersBOT, the D-Backs (+1.5) are a 61% chance of covering the run line, while the Over/Under total of 11.5 runs is a 57% chance of going Under.

More: Free Prop Picks

Best Bets for D-Backs vs. Cubs

• Run Line: D-Backs +1.5 @ -145 via Caesars Sportsbook (61% probability)
• Moneyline: D-Backs @ +125 via DraftKings Sportsbook (1.4% edge)
• Total: Under 11.5 @ -115 via Caesars Sportsbook (57% probability)

Dimers' best bets are based on detailed simulations and wagering intelligence to serve you the best possible plays every day of the year.

While the Cubs are more likely to win the game, according to DimersBOT, taking the D-Backs moneyline is the best option because of the 1.4% edge identified when comparing our data-led probabilities to the sportsbooks' odds currently available.

Taking advantage of the edges published on Dimers.com is one of the keys to achieving long-term profitability as a bettor.

D-Backs vs. Cubs Probabilities

Use our interactive widget below to view up-to-date Moneyline, Over/Under and Run Line probabilities and odds for Arizona vs. CHI Cubs, and click or tap on See Matchup for more.

Dimers has full coverage of Friday's D-Backs-Cubs matchup, including pregame predictions, best betting picks, and live win probabilities.

Remember, DimersBOT updates regularly, so keep checking this page for the latest betting analysis before D-Backs vs. Cubs on Friday May 20, 2022.

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Note: when you click or tap on a link on Dimers that leads to a third-party website that we have a commercial arrangement with (such as a sportsbook), we may earn a referral fee.

D-Backs vs. Cubs 2022 Game Info

Friday's game between the Cubs and D-Backs at Wrigley Field is scheduled to start at 2:20PM ET.

• Date: Friday May 20, 2022
• Time: 2:20PM ET / 11:20AM PT
• Venue: Wrigley Field

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Want more MLB predictions like this?

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We use the power of predictive analytics to find edges in the markets so we can write the best MLB betting previews available. We do this by comparing our in-house probabilities against the sportsbooks' odds (aka Vegas odds) the minute they go live.

So, get ahead of the game and beat the bookies today – it's only a click away.

Lastly, Dimers' Baseball Futures page is our in-house approach to revealing who will win the 2022 World Series, with our data-led probabilities matched against the best odds to win the World Series.