Cubs vs. White Sox Prediction and Odds - May 28, 2022

The Chicago White Sox face the Chicago Cubs in MLB action at Guaranteed Rate Field on Saturday, commencing at 7:15PM ET.

The White Sox will have Johnny Cueto (0-0, 0.00 ERA) start, pitting him against Keegan Thompson (4-0, 1.54 ERA) for the Cubs.

Dimers' top betting picks for Cubs vs. White Sox, as well as game predictions and best odds, are detailed below.

Today's CHI Cubs vs. CHI White Sox betting preview is sponsored by PointsBet, which has a great 5x $100 Risk-Free Bets promo for new users.

Who will win Cubs vs. White Sox?

Based on cutting-edge computer power and data, Dimers.com has simulated Saturday's Cubs-White Sox MLB matchup 10,000 times.

Dimers' leading predictive analytics model, DimersBOT, currently gives the White Sox a 59% chance of getting the W against the Cubs.

More: Free Betting Guide for Cubs vs. White Sox

Cubs vs. White Sox Current Odds

• Run Line: White Sox -1.5 (+146), Cubs +1.5 (-160)
• Moneyline: White Sox -140, Cubs +125
• Total: Over/Under 8 (-105/-110)

Run Line, Moneyline and Over/Under

The White Sox are currently -1.5 favorites versus the Cubs, with +146 at FanDuel Sportsbook the best odds currently available.

For the underdog Cubs (+1.5) to cover the run line, DraftKings Sportsbook has the best odds currently on offer at -160.

PointsBet currently has the best moneyline odds for the White Sox at -140, which means you can risk $140 to win $100, for a total payout of $240, if they get the W.

On the other hand, DraftKings Sportsbook currently has the best moneyline odds for the Cubs at +125, where you can bet $100 to profit $125, earning a total payout of $225, if they win.

The Over/Under sits at 8 with BetMGM, which currently has the best odds for the Over at -105, while Caesars Sportsbook currently has the best odds for the Under at -110.

As always, make sure you check the sportsbooks you have access to in your state for the best MLB odds and lines.

According to DimersBOT, the Cubs (+1.5) are a 61% chance of covering the run line, while the 8-run Over/Under is considered an equal 50-50 chance of hitting.

More: Free Prop Picks

Best Bets for Cubs vs. White Sox

• Run Line: Cubs +1.5 @ -160 via DraftKings Sportsbook (61% probability)
• Moneyline: White Sox @ -140 via PointsBet (59% probability)
• Total: Over 8 @ -105 via BetMGM (50% probability)

Dimers' best bets are based on world-class simulations and betting intelligence to serve you the best possible plays every day of the year.

Cubs vs. White Sox Betting Guide

Use our widget below to see up-to-date Moneyline, Over/Under and Run Line probabilities and odds for CHI Cubs vs. CHI White Sox, and click or tap on See Matchup for more.

Dimers has full betting coverage of Saturday's Cubs-White Sox matchup, including pregame predictions, free picks, and live win probabilities.

Don't forget, DimersBOT updates regularly, so keep an eye on this page for any changes to our betting insights before Cubs vs. White Sox on Saturday May 28, 2022.

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Note: when you click or tap on a link on Dimers that leads to a third-party website that we have a commercial arrangement with (such as a sportsbook), we may earn a referral fee.

Cubs vs. White Sox 2022 Game Info

Saturday's game between the White Sox and Cubs at Guaranteed Rate Field is scheduled to begin at 7:15PM ET.

• Who: Chicago White Sox vs. Chicago Cubs
• Date: Saturday May 28, 2022
• Time: 7:15PM ET / 4:15PM PT
• Venue: Guaranteed Rate Field

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What MLB games are on today?

Now you've got the 411 on Cubs vs. White Sox, see the latest betting coverage for all upcoming MLB games in our MLB Bet Hub. There you can find probabilities and odds, and our best bets for each and every MLB matchup.

Want a pick for the Run Line? You got it. How about the Over/Under? Yup, got that too. The Moneyline? Yes sir. And these picks are good, I mean REALLY good. Take a look now!

While you're here, Dimers' MLB Futures page is our in-house approach to determining who will win the 2022 World Series, with our data-led probabilities paired with the best odds to win the World Series.