Cubs vs. Pirates Prediction and Odds - Jun 22, 2022

MLB action continues on Wednesday at 7:05PM ET as the Chicago Cubs take on the Pittsburgh Pirates at PNC Park.

The Pirates will send Zach Thompson (3-5, 4.47 ERA) to the mound, while the Cubs are going with Keegan Thompson (6-2, 3.27 ERA).

Dimers' best betting picks for Cubs vs. Pirates, as well as game predictions and best odds, are featured in this article.

Who will win Cubs vs. Pirates?

Based on trusted computer power and data, Dimers.com has simulated Wednesday's Cubs-Pirates MLB game 10,000 times.

Dimers' leading predictive analytics model, DimersBOT, gives the Pirates a 57% chance of winning against the Cubs.

More: Cubs vs. Pirates Simulated 10,000 Times

Cubs vs. Pirates Game Odds

• Moneyline: Pirates +120, Cubs -125
• Total: Over/Under 9 (-114/-105)

Run Line, Moneyline and Over/Under

DraftKings Sportsbook currently has the best moneyline odds for the Pirates at +120. That means you can bet $100 to profit $120, earning a total payout of $220, if they win.

Meanwhile, Caesars Sportsbook currently has the best moneyline odds for the Cubs at -125, where you can risk $125 to win $100, for a total payout of $225, if they come out on top.

The Over/Under sits at 9 with FanDuel Sportsbook, which currently has the best odds for the Over at -114, while PointsBet currently has the best odds for the Under at -105.

As always, check out all the sportsbooks available in your state for the best MLB odds and lines.

According to DimersBOT, the 9-run Over/Under is a 52% chance of going Under.

More: Best Prop Bets Today

Best Bets for Cubs vs. Pirates

• Moneyline: Pirates @ +120 via DraftKings Sportsbook (57% probability) 🔥
• Total: Under 9 @ -105 via PointsBet (52% probability)

Any time you see a 🔥, that means it's one of Dimers' best free picks today across all major pro and college sports.

Our best bets are based on world-class simulations and gambling expertise to help you make more informed decisions with the legal sportsbooks in your state.

Cubs vs. Pirates Prediction

Use our interactive widget below to explore the latest Moneyline, Over/Under and Run Line probabilities and odds for CHI Cubs vs. Pittsburgh, and click or tap on See Matchup to reveal more.

Dimers has full coverage of Wednesday's Cubs-Pirates matchup, including pregame predictions, top betting picks, and live scores.

Remember, DimersBOT updates regularly, so keep an eye on this page for the latest betting analysis ahead of Cubs vs. Pirates on Wednesday June 22, 2022.

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Note: When you click or tap on a link on Dimers that leads to a third-party website that we have a commercial relationship with (such as a sportsbook), we may earn a referral fee.

Cubs vs. Pirates 2022 Game Info

Wednesday's game between the Pirates and Cubs at PNC Park is scheduled to begin at 7:05PM ET.

• Who: Pittsburgh Pirates vs. Chicago Cubs
• Date: Wednesday June 22, 2022
• Time: 7:05PM ET / 4:05PM PT
• Venue: PNC Park

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Want more MLB predictions like this?

To get more MLB betting previews like you've just read for Cubs vs. Pirates, all you've gotta do is visit Dimers' MLB Betting News section. It's that easy – they're all there!

We use the power of predictive analytics to find edges in the markets so we can produce the most comprehensive MLB betting previews out there. We're able to do this by comparing our own probabilities against the sportsbooks' odds (aka Vegas odds) as soon as they go live.

So, get ahead of the game and beat the bookies today – it's only a click away.

Lastly, Dimers' MLB Futures page is our in-house approach to determining who will win the 2022 World Series, with our data-led probabilities matched against the best odds available.