Cubs vs. Pirates Prediction and Odds - Jun 21, 2022

The Pittsburgh Pirates take on the Chicago Cubs in MLB action at PNC Park on Tuesday, commencing at 7:05PM ET.

Roansy Contreras (1-1, 3.06 ERA) will start for the Pirates, while the Cubs will counter with Matt Swarmer (1-2, 5.23 ERA).

Dimers' best betting picks for Cubs vs. Pirates, as well as game predictions and betting odds, are detailed below.

Who will win Cubs vs. Pirates?

Based on cutting-edge machine learning and data, Dimers.com has simulated Tuesday's Cubs-Pirates MLB game 10,000 times.

Dimers' popular predictive analytics model, DimersBOT, currently gives the Pirates a 60% chance of getting the W against the Cubs.

More: Cubs vs. Pirates Simulated 10K Times

Cubs vs. Pirates Game Odds

• Run Line: Pirates -1.5 (+140), Cubs +1.5 (-155)
• Moneyline: Pirates -145, Cubs +130
• Total: Over/Under 9 (-105/-105)

Run Line, Moneyline and Over/Under

The Pirates are currently -1.5 favorites against the Cubs, with +140 at DraftKings Sportsbook the best odds currently available.

For the underdog Cubs (+1.5) to cover the run line, BetMGM has the best odds currently on offer at -155.

PointsBet currently has the best moneyline odds for the Pirates at -145, which means you can risk $145 to win $100, for a total payout of $245, if they get the W.

Elsewhere, Caesars Sportsbook currently has the best moneyline odds for the Cubs at +130, where you can bet $100 to profit $130, earning a total payout of $230, if they win.

The Over/Under for total runs scored sits at 9 with PointsBet, which currently has the best odds for the Over at -105, while BetMGM currently has the best odds for the Under at -105.

As always, make sure you check all of the sportsbooks that are available in your state for the best MLB odds and lines.

According to DimersBOT, the Cubs (+1.5) are a 58% chance of covering the run line, while the 9-run Over/Under is a 53% chance of going Under.

More: Best Prop Bets Today

Best Bets for Cubs vs. Pirates

• Run Line: Pirates -1.5 @ +140 via DraftKings Sportsbook (0.6% edge)
• Moneyline: Pirates @ -145 via PointsBet (60% probability)
• Total: Under 9 @ -105 via BetMGM (53% probability)

Dimers' best bets are based on complex simulations and betting expertise to help you make smarter investments with your state's legal sportsbooks.

Although the Cubs are more likely to cover the run line, our best bet of Pirates -1.5 is based on the chance of that happening, according to DimersBOT, and the best odds available.

Cubs vs. Pirates Betting Guide

Use our interactive widget below to see up-to-date Moneyline, Over/Under and Run Line probabilities and odds for CHI Cubs vs. Pittsburgh, and click or tap on See Matchup to reveal more.

Dimers has full betting coverage of Tuesday's Cubs-Pirates matchup, including pregame predictions, free picks, and live scores.

Don't forget, DimersBOT updates often, so check this page for any changes to our betting analysis before Cubs vs. Pirates on Tuesday June 21, 2022.

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Cubs vs. Pirates 2022 Game Info

Tuesday's matchup between the Pirates and Cubs at PNC Park is scheduled to start at 7:05PM ET.

• Who: Pittsburgh Pirates vs. Chicago Cubs
• Date: Tuesday June 21, 2022
• Time: 7:05PM ET / 4:05PM PT
• Venue: PNC Park

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What other MLB games are on today?

Now you've got the 411 on Cubs vs. Pirates, take a look at the latest betting analysis for all upcoming MLB games in our MLB Bet Hub. There you can find probabilities and odds, and our best bets for each and every MLB matchup.

Want a pick for the Run Line? You got it. How about the Over/Under? Yup, got that too. The Moneyline? Yes sir. And these picks are good, I mean REALLY good. Take a look now!

While you're here, Dimers' Baseball Futures page is our in-house approach to determining who will win the 2022 World Series, with our data-led probabilities paired with the best odds available.