Chicago Cubs vs. St. Louis Cardinals Prediction, Odds, MLB Picks [5/25/2024]

Chicago Cubs vs. St. Louis Cardinals Prediction, Odds, MLB Picks [5/25/2024]

The St. Louis Cardinals will face the Chicago Cubs in MLB action at Busch Stadium on Saturday, beginning at 7:15PM ET.

The Cardinals will send Miles Mikolas (3-5, 5.77 ERA) to the mound, while the Cubs have opted for Jameson Taillon (3-2, 2.20 ERA).'s in-depth preview of Saturday's Cubs vs. Cardinals matchup includes our prediction, picks and the latest betting odds.

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Cubs vs. Cardinals Prediction: Who Will Win, Cover the Run Line

We have used advanced machine learning and data to simulate the outcome of Saturday's MLB matchup between the Cubs and Cardinals 10,000 times, in line with our coverage of MLB predictions.

Our independent predictive analytics model currently gives the Cardinals a 51% chance of beating the Cubs.

According to our model, the Cardinals (+1.5) have a 63% chance of covering the run line, while the 8.5-run over/under has a 51% chance of going over.

Cubs vs. Cardinals Odds [5/25/2024]

We have researched the best betting odds in America for this game, which are listed here:

Bet Type Cubs Cardinals
Run Line -1.5 (+146) +1.5 (-178)
Moneyline -108 -108
Total o8.5 (-112) u8.5 (-108)

All odds are correct at the time of publication and are subject to change.

Cubs vs. Cardinals Picks

At Dimers, our predictions, paired with the latest odds, reveal the top betting picks for every game, including Cubs vs. Cardinals. Our MLB best bets are based on expert modeling and analysis, as you can see.

Improve your odds with Dimers Pro. Through Dimers Pro, we give you the tools and information to succeed with hundreds of data-driven bets across thousands of games. Join now to find any potential picks for this matchup.


Cubs vs. Cardinals Game Information

Saturday's MLB matchup between the Cardinals and Cubs at Busch Stadium is scheduled to start at 7:15PM ET.


Our full coverage of the Cubs vs. Cardinals includes pregame predictions, betting picks and live updates.

Calling Our Shot: Free ⚾️ Picks

Calling Our Shot produces daily MLB betting content, including the best bets featured below.


We predict the Cardinals, with a 51% win probability, will likely beat the Cubs on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Cubs vs. Cardinals insights, with human oversight ensuring high editorial quality. Our predictions are rooted in current data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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Dave Garofolo
Content Producer

Dave Garofolo, a seasoned fantasy sports and betting enthusiast with a special affection for MLB and NFL, uses his deep knowledge to craft game previews for the NBA, MLB, and NFL. He also brings his expertise to the golf world with tournament previews and parlays for the PGA TOUR and major golf tournaments. Additionally, Dave offers valuable props for NBA, MLB, NHL, and NCAAM basketball, along with best bets for MLB, NHL, and NCAAM. 

When not delving into the world of sports, Dave is an avid advocate for New Haven pizza, enjoys reading comic books, gardening, and spending time with his cats. His broad interests and detailed sports insights ensure that his contributions are both engaging and informative.

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