Cardinals vs. Pirates Prediction and Odds - May 20, 2022

The Pittsburgh Pirates face the St Louis Cardinals in MLB action at PNC Park on Friday, beginning at 6:35PM ET.

The Pirates will have Zach Thompson (2-3, 5.47 ERA) start, pitting him against Adam Wainwright (4-3, 3.15 ERA) for the Cardinals.

Dimers' best betting picks for Cardinals vs. Pirates, plus game predictions and best odds, are featured below.

Today's St Louis vs. Pittsburgh betting analysis is proudly sponsored by PointsBet, which has an awesome 5x $100 Risk-Free Bets offer for new users.

Who will win Cardinals vs. Pirates?

Using high-tech machine learning and data, Dimers.com has simulated Friday's Cardinals-Pirates MLB game 10,000 times.

Dimers' proven predictive analytics model, DimersBOT, currently gives the Cardinals a 57% chance of getting the W against the Pirates .

More: Cardinals vs. Pirates Simulated 10K Times

Cardinals vs. Pirates Game Odds

• Run Line: Pirates +1.5 (-125), Cardinals -1.5 (+118)
• Moneyline: Pirates +130, Cardinals -144
• Total: Over/Under 8.5 (-115/-104)

Run Line, Moneyline and Over/Under

The Pirates are +1.5 underdogs against the Cardinals, with -125 at BetMGM the best odds currently available.

For the favored Cardinals (-1.5) to cover the run line, FanDuel Sportsbook has the best odds currently on offer at +118.

Caesars Sportsbook currently has the best moneyline odds for the Pirates at +130. That means you can bet $100 to profit $130, earning a total payout of $230, if they win.

Meanwhile, FanDuel Sportsbook currently has the best moneyline odds for the Cardinals at -144, where you can risk $144 to win $100, for a total payout of $244, if they come out on top.

The Over/Under sits at 8.5 with PointsBet, which currently has the best odds for the Over at -115, while FanDuel Sportsbook currently has the best odds for the Under at -104.

As always, check out the sportsbooks you can bet with in your state for the best MLB odds and lines.

According to DimersBOT, the Pirates (+1.5) are a 55% chance of covering the run line, while the Over/Under total of 8.5 runs is a 54% chance of going Over.

More: Best Prop Bets to Make Today

Best Bets for Cardinals vs. Pirates

• Run Line: Pirates +1.5 @ -125 via BetMGM (55% probability)
• Moneyline: Pirates @ +130 via Caesars Sportsbook
• Total: Over 8.5 @ -115 via PointsBet (54% probability)

Dimers' best bets are based on world-class simulations and betting intelligence to help you make smarter decisions with the legal sportsbooks in the USA.

While the Cardinals are more likely to win the game, according to DimersBOT, betting on the Pirates moneyline is the best option due to the edge found when comparing our data-led probabilities to the sportsbooks' odds currently on offer.

Taking advantage of the edges published on Dimers is crucial to achieving long-term profitability as a bettor.

Cardinals vs. Pirates Betting Guide

Use our interactive widget below to view up-to-date Moneyline, Over/Under and Run Line probabilities and odds for St Louis vs. Pittsburgh, and click or tap on See Matchup to reveal more.

Dimers has full coverage of Friday's Cardinals-Pirates matchup, including pregame predictions, best betting picks, and live win probabilities.

Remember, DimersBOT updates often, so check this page for the latest betting insights before Cardinals vs. Pirates on Friday May 20, 2022.

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Cardinals vs. Pirates 2022 Game Info

Friday's matchup between the Pirates and Cardinals at PNC Park is scheduled to commence at 6:35PM ET.

• Date: Friday May 20, 2022
• Time: 6:35PM ET / 3:35PM PT
• Venue: PNC Park

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Want more MLB previews like this?

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We use the power of predictive analytics to find edges in the markets so we can publish the best MLB betting previews out there. We do this by comparing our own probabilities against the sportsbooks' odds (aka Vegas odds) as soon as they go live.

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Finally, Dimers' MLB Futures page is our in-house approach to revealing who will win the 2022 World Series, with our data-led probabilities matched against the best odds on the market.