Buffalo Bills vs. Los Angeles Chargers Prediction, Odds, NFL Picks - Week 16 [2023]

Buffalo Bills vs. Los Angeles Chargers Prediction, Odds, NFL Picks - Week 16 [2023]

The Los Angeles Chargers and Buffalo Bills will meet in Week 16 of the NFL season at SoFi Stadium on Saturday, with kickoff at 8:00PM ET.

Dimers.com's comprehensive betting preview for Saturday's Bills vs. Chargers matchup includes the latest betting odds, as well as our predictions and picks for the game.

Bills vs. Chargers Prediction: Who Will Win, Cover the Spread

We have used advanced machine learning and data analysis to simulate the outcome of Saturday's NFL game between the Bills and Chargers 10,000 times, in line with our coverage of NFL picks.

Our famous predictive analytics model gives the Bills an 89% chance of defeating the Chargers in Week 16 of the NFL season, and our predicted final score has the Bills winning 28-15.

According to our model, the Bills (-12.5) have a 51% chance of covering the spread, while the 44.5-point Over/Under has a 56% chance of going under.

Today's Buffalo vs. LA Chargers betting preview is proudly sponsored by Bet365, which has an awesome Bet $5, Get $150 in Bonus Bets offer for new customers.

Bills vs. Chargers Odds

We have researched the best betting odds in America for this game, which are listed here:

Bet Type Bills Chargers
Spread -12.5 (-105) +12.5 (-110)
Moneyline -750 +550
Total o44.5 (-105) u44.5 (-110)
  • The Chargers are +12.5 underdogs against the Bills, with -110 at BetMGM Sportsbook the best odds currently available.
  • For the favored Bills (-12.5) to cover the spread, FanDuel Sportsbook has the best odds currently on offer at -105.
  • BetMGM currently has the best moneyline odds for the Chargers at +550. That means you can throw down $100 to profit $550, earning a total payout of $650, if they win.
  • On the other hand, FanDuel currently has the best moneyline odds for the Bills at -750, where you can risk $750 to win $100 for a total payout of $850 if they come out on top.
  • The Over/Under for total points scored sits at 44.5 with DraftKings Sportsbook, which currently has the best odds for the Over at -105, while FanDuel currently has the best odds for the Under at -110.

All odds are correct at the time of publication and are subject to change.

As always, make sure you check the sportsbooks you can bet with in your state for the best NFL odds and lines.

Bills vs. Chargers Picks

By comparing our probabilities to the odds listed above, we have determined the best betting picks to make on this game:

Bet Type Our Pick Best Odds
Spread Bills -12.5 -105
Moneyline Bills -750
Total Under 44.5 -110


Dimers' NFL best bets are based on world-class simulations and wagering intelligence to bring you the best possible plays every week of the season.

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Bills vs. Chargers TD Scorers

Who will score the first touchdown in Bills vs. Chargers?

According to our model, Buffalo's James Cook is most likely to score the first TD in Bills vs. Chargers.

Our projections give Cook a 12.1% chance of scoring the first TD at SoFi Stadium, while the Bills RB is a 47.1% chance of scoring an anytime touchdown.

First Touchdown Scorer Predictions

Buffalo Bills

Player First TD Probability
James Cook 12.1%
Josh Allen 11.3%
Stefon Diggs 9.8%
Gabe Davis 7.4%
Dalton Kincaid 6.0%

Los Angeles Chargers

Player First TD Probability
Austin Ekeler 7.2%
Joshua Palmer 4.6%
Gerald Everett 4.4%
Quentin Johnston 3.3%
Isaiah Spiller 3.1%

Anytime Touchdown Scorer Predictions

Buffalo Bills

Player Anytime TD Probability
James Cook 47.1%
Josh Allen 44.9%
Stefon Diggs 40.0%
Gabe Davis 30.7%
Dalton Kincaid 26.2%

Los Angeles Chargers

Player Anytime TD Probability
Austin Ekeler 32.7%
Joshua Palmer 22.4%
Gerald Everett 20.4%
Quentin Johnston 16.0%
Isaiah Spiller 14.5%

Bills vs Chargers Player Props

Here, you will find detailed projections for all of the key offensive players from the Bills and Chargers, including passing, rushing and receiving yards.

Bills vs. Chargers Quarterbacks

Of the starting quarterbacks, the Bills' Josh Allen is projected for 253 passing yards. The Chargers' Easton Stick is expected to throw for just 186 yards.

Player Proj. Pass Yards
Josh Allen (BUF) 253 yds
Easton Stick (LAC) 186 yds

Bills Rushing

Player Proj. Rush Yards
James Cook 60 yds
Latavius Murray 28 yds
Josh Allen 19 yds

Chargers Rushing

Player Proj. Rush Yards
Austin Ekeler 44 yds
Isaiah Spiller 25 yds
Easton Stick 18 yds

Bills Receiving

Player Proj. Rec. Yards
Stefon Diggs 80 yds
Dalton Kincaid 38 yds
Gabe Davis 32 yds
James Cook 22 yds
Khalil Shakir 21 yds

Chargers Receiving

Player Proj. Rec. Yards
Gerald Everett 41 yds
Joshua Palmer 40 yds
Quentin Johnston 34 yds
Austin Ekeler 26 yds
Jalen Guyton 23 yds

Remember, our model updates often, so keep an eye on this article for any changes to our betting insights before the Bills vs. Chargers on Saturday December 23, 2023.

Bills vs. Chargers Game Information

The NFL Week 16 matchup between the Chargers and Bills at SoFi Stadium is scheduled to begin at 8:00PM ET.


Our full coverage of Bills vs. Chargers includes pregame predictions, betting picks, and live updates.

How to Bet on Bills vs. Chargers

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This preview article has been partially generated using automated processes and AI technology. Our goal is to provide timely and accurate updates on Bills vs. Chargers Week 14 clash, and automation assists in data collection, analysis, and formatting. Human editing and quality control are performed to ensure the content meets our editorial standards.

Dimers' predictions are made thanks to 10,000 simulations per game, using reliable and up-to-date data sources and analytical methods. While these Bills vs. Chargers picks can help you make informed decisions, it's important that you gamble responsibly and manage your finances effectively.

For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

When you click or tap on a link on Dimers that leads to a third-party website that we have a commercial arrangement with (such as a sportsbook), we may get a referral fee at no additional cost to you.

More on NFL

Stay updated with the latest NFL betting news and our data-led NFL picks and parlays all season long. Plus, our Super Bowl odds give you the latest predictions and the best available odds on the Super Bowl, AFC, NFC, and each division.

Ryan Leaver
Senior Sports and Sports Betting Editor

Ryan Leaver is a seasoned sports betting expert specializing in NBA, NFL, college football, college basketball, and soccer, offering detailed game previews, best bets, props, and futures articles.

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