Best MLB Betting Picks and Parlay - Friday, September 23, 2022

A look at our best bets and a special Friday MLB parlay.

It's Friday, September 23, 2022, and, as always, we've simulated all of the day's MLB games 10,000 times each to determine where the value lies for sports bettors across the United States.

With our MLB best bets, probabilities, and odds featured each and every day, check out our best betting picks for Friday's MLB games below.

Today's best MLB prop bets and odds are proudly brought to you by DraftKings Sportsbook.

Not with DraftKings yet? Well, sign up now and you'll get access to the best new customer MLB offer available. It's a bet $5 and get $100 no matter what offer, so simply click ➡️ here ⬅️, or tap the yellow button below.


Best MLB Bets Today

Red Sox vs. Yankees, 7:05PM ET

The scene is well and truly set in the Bronx tonight for Aaron Judge to hit home run No. 61 against New York's old foe, but don't expect the scoring opportunities to just be limited to the Yankees tonight. Gerrit Cole (12-7, 3.41 ERA) is on the bump for the Yanks, and even though they've been winning when he starts, opposition hitters have still been feasting with an average of 2.7 runs given up per start over his last 10 games, including a massive 8 runs through his last two starts where he's given up 5 home runs in the process too. Look for the runs to flow on both sides tonight.

BET: Total runs OVER 8 (-108). Place this bet with DraftKings Sportsbook ➡️ here ⬅️.


⚾️ Red Sox vs. Yankees Predictions
📈 Betting preview: Red Sox vs. Yankees

Astros vs. Orioles, 7:05PM ET

Houston suffered an uncharacteristic shutout loss to the O's in their weekend series opener last night, even with the impenetrable Justin Verlander on the bump for the Astros. While their run offense was unable to provide any support, going down 2-0, a repeat of that is unlikely to occur tonight with the 'Stros never going consecutive games scoreless this season. The main concern for Houston tonight will be trying to lock things down defensively with starting ace José Urquidy (13-7, 3.96 ERA) suffering through a rough patch right now, clocking up a 6.00 ERA over his last three starts. This one could be a shootout, with a relatively low total a chance to be exploited.

BET: Total runs OVER 7.5 (-106). with DraftKings Sportsbook. Click ➡️ here ⬅️ to place your bet.


⚾️ Astros vs. Orioles Predictions
📈 Betting preview: Astros vs. Orioles

Guardians vs. Rangers, 8:05PM ET

Cleveland navigated through back-to-back series over interdivisional rivals in the Twins and White Sox in emphatic fashion over the past week to all but cement themselves as the AL Central winners and book their spot in the postseason. With the highs of the last few games, are they due a let down game against a lesser opponent in the Rangers? Nah. This team is humming right now, and they have everything they need to keep going strong. The relatively inexperienced Cody Morris (0-2, 2.30 ERA) will be pitching for the Guards, but despite his record, he has been a solid addition to the rotation in recent weeks, only giving up 5 runs across his first 5 career starts. If the Cleveland offense can fire, they'll add another W to the column.

BET: Guardians moneyline (+100). Want to tail this pick? Do it with DraftKings Sportsbook and get a nice bonus while doing so by clicking ➡️ here ⬅️.


⚾️ Guardians vs. Rangers Predictions
📈 Betting preview: Guardians vs. Rangers

Your game not here? Find out who we're betting on for every baseball game on Friday via our MLB Bet Hub, where we deliver you MLB predictions and suggested bets, or check out the MLB Betting News section.

Best MLB Parlay Today

There are numerous different ways you can wager on MLB games in 2022, such as the moneyline, run line, total, player and team props (strikeouts, RBIs, and home runs), and, of course, parlays. Given the high-risk, high reward nature of parlays, we're going to use the DraftKings Bet $5, win $100 no matter what promo to guarantee a big cash.

Here's how to do it.

First, create your DraftKings account ➡️ here ⬅️, then make your first deposit of at least $5. Use that $5 to place a parlay using the below plays. If the parlay hits, you get yourself a nice payout, plus that $100 bonus. If it doesn't hit, well you've still got $100 free from DraftKings just for betting on MLB. Win-win!

🔥 Red Sox-Yankees o8 runs
🔥 Astros-Orioles o7.5 runs
🔥 Guardians ML


MORE: Friday's MLB Props and Parlay

*All odds and lines correct at time of publishing

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