Astros vs. Orioles Prediction and Odds - Sep 23, 2022

The Baltimore Orioles take on the Houston Astros in MLB action at Oriole Park at Camden Yards on Friday, commencing at 7:05PM ET.

The Orioles will send Dean Kremer (7-5, 3.33 ERA) to the mound, while the Astros are going with José Urquidy (13-7, 3.96 ERA).

Dimers' top betting picks for Astros vs. Orioles, as well as game predictions and betting odds, are featured in this article.


Who will win Astros vs. Orioles?

Using state-of-the-art computer power and data, has simulated Friday's Astros-Orioles MLB game 10,000 times.

Dimers' popular predictive analytics model, DimersBOT, gives the Astros a 54% chance of winning against the Orioles.

More: Astros vs. Orioles Simulated 10,000 Times

Astros vs. Orioles Odds

  • Run Line: Orioles +1.5 (-135), Astros -1.5 (+125)
  • Moneyline: Orioles +122, Astros -138
  • Total: Over/Under 7.5 (-110/+100)

Run Line, Moneyline and Over/Under

The Orioles are currently +1.5 underdogs versus the Astros, with -135 at Caesars Sportsbook the best odds currently available.

For the favored Astros (-1.5) to cover the run line, BetMGM has the best odds currently on offer at +125.

Caesars Sportsbook currently has the best moneyline odds for the Orioles at +122, which means you can bet $100 to profit $122, earning a total payout of $222, if they win.

Elsewhere, FanDuel Sportsbook currently has the best moneyline odds for the Astros at -138, where you can risk $138 to win $100, for a total payout of $238, if they come out on top.

The Over/Under is set at 7.5 with DraftKings Sportsbook, which currently has the best odds for the Over at -110, while BetMGM currently has the best odds for the Under at +100.

As always, check out the sportsbooks you have access to in your state for the best MLB odds and lines.

According to DimersBOT, the Orioles (+1.5) are a 57% chance of covering the run line, while the 7.5-run Over/Under is a 61% chance of going Over.

More: Track Your Bets via Bet Center

Best Bets for Astros vs. Orioles


When you see a 🔥, that means it's one of our best bets today across all major pro and college sports.

Our best bets are based on world-class simulations and betting expertise to help you make more informed decisions with the legal sportsbooks in your state.

While the Astros are more likely to win the game, according to DimersBOT, taking the Orioles moneyline is the best option because of the edge found when comparing our data-led probabilities to the sportsbooks' odds currently on offer.

Taking advantage of the edges published here at is crucial to achieving long-term profitability as a sports bettor.

Astros vs. Orioles Prediction

Click or tap on See Matchup for more.


Dimers has full coverage of Friday's Astros-Orioles matchup, including pregame predictions, best betting picks, and live scores.

Remember, DimersBOT updates often, so check this page for the latest betting insights ahead of Astros vs. Orioles on Friday September 23, 2022.


Astros vs. Orioles 2022 Game Info

Friday's matchup between the Orioles and Astros at Oriole Park at Camden Yards is scheduled to begin at 7:05PM ET.

  • Who: Houston Astros vs. Baltimore Orioles
  • Date: Friday September 23, 2022
  • Time: 7:05PM ET / 4:05PM PT
  • Venue: Oriole Park at Camden Yards

Enjoy and want to keep the site free? Every time you join a sportsbook featured here, we get paid a small fee.

These fees help us keep Dimers free for sports fans like you. So, if you like what you see, support us by joining one of our featured sports betting partners.

Want more MLB analysis like this?

So, you liked our Astros vs. Orioles betting analysis? Awesome. Did you know our MLB Betting News section has a detailed betting preview for every MLB matchup as soon as the sportsbooks release their odds?

That's right, our predictive analytics model then compares those odds (aka Vegas odds) against its own probabilities to find edges in the markets, which allows us to create the most accurate MLB betting previews and get the jump on the public and the sportsbooks.

It's only a click away, so why not see for yourself?

Lastly, Dimers' MLB Futures page is our in-house approach to determining who will win the 2022 World Series, with our data-led probabilities compared to the best odds on the market.

Related Articles
More Articles