Baltimore Orioles vs. St. Louis Cardinals Prediction, Odds, MLB Picks [5/22/2024]

Baltimore Orioles vs. St. Louis Cardinals Prediction, Odds, MLB Picks [5/22/2024]

MLB action continues on Wednesday at 1:15PM ET as the Baltimore Orioles lock horns with the St. Louis Cardinals at Busch Stadium.

The Cardinals will start Kyle Gibson (3-2, 4.09 ERA), up against John Means (2-0, 3.06 ERA) for the Orioles.'s comprehensive preview of Wednesday's Orioles vs. Cardinals matchup includes our prediction, picks and the latest betting odds.

JOIN NOW: For exclusive access to hundreds of data-driven bets daily across thousands of games for less than $1 a day, sign up to Dimers Pro today.

Orioles vs. Cardinals Prediction: Who Will Win, Cover the Run Line

We have used powerful machine learning and statistical analysis to simulate the result of Wednesday's MLB matchup between the Orioles and Cardinals 10,000 times, in keeping with our coverage of MLB picks.

Our independent predictive analytics model gives the Orioles a 54% chance of beating the Cardinals.

According to our model, the Cardinals (+1.5) have a 60% chance of covering the run line, while the over/under total of 9 runs has a 53% chance of going under.

Orioles vs. Cardinals Odds [5/22/2024]

We have researched the best betting odds in America for this game, which are listed here:

Bet Type Orioles Cardinals
Run Line -1.5 (+135) +1.5 (-150)
Moneyline -125 +110
Total o9 (-110) u9 (-110)

All odds are correct at the time of publication and are subject to change.

Orioles vs. Cardinals Picks

At Dimers, our predictions, coupled with the current odds, reveal the top betting picks to make on every game, including Orioles vs. Cardinals. Our MLB best bets are based on expert modeling and analysis, as you can see.

Dimers Pro unlocks +EV bets daily. Dimers Pro subscribers get hundreds of data-driven bets daily across thousands of games. Join now to get instant access and see any potential picks for this matchup.


Orioles vs. Cardinals Game Information

Wednesday's MLB game between the Cardinals and Orioles at Busch Stadium is scheduled to begin at 1:15PM ET.


Our full betting coverage of the Orioles vs. Cardinals includes pregame predictions, betting picks and live win probabilities.

Calling Our Shot: Free MLB Picks

Calling Our Shot produces daily MLB betting content, including the latest predictions featured below.


We predict the Orioles, with a 54% win probability, will likely beat the Cardinals on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Orioles vs. Cardinals insights, with human oversight ensuring high editorial quality. Our predictions are grounded in current data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee.

More on MLB

Stay up-to-date with the latest MLB news and our analytics-driven MLB picks and parlays all season long. Plus, our World Series odds give you the latest numbers and the best available odds on the World Series, American League, National League, and each division.

Dave Garofolo
Content Producer

Dave Garofolo, a seasoned fantasy sports and betting enthusiast with a special affection for MLB and NFL, uses his deep knowledge to craft game previews for the NBA, MLB, and NFL. He also brings his expertise to the golf world with tournament previews and parlays for the PGA TOUR and major golf tournaments. Additionally, Dave offers valuable props for NBA, MLB, NHL, and NCAAM basketball, along with best bets for MLB, NHL, and NCAAM. 

When not delving into the world of sports, Dave is an avid advocate for New Haven pizza, enjoys reading comic books, gardening, and spending time with his cats. His broad interests and detailed sports insights ensure that his contributions are both engaging and informative.

On the socials
More from Dimers
About Dimers
icon 22,000+
Events covered per year
icon 8,000,000+
Our partners