Astros vs. Red Sox Prediction and Odds - May 18, 2022

The Boston Red Sox and Houston Astros meet in MLB at Fenway Park on Wednesday, starting at 6:10PM ET.

The Red Sox will have Nick Pivetta (1-4, 5.08 ERA) start, pitting him against Luis Garcia (3-1, 2.94 ERA) for the Astros.

Dimers' top betting picks for Astros vs. Red Sox, plus game predictions and best odds, are detailed in this article.

This Houston vs. Boston betting analysis is presented by PointsBet, which has a tasty 5x $100 Risk-Free Bets offer for new users.

Who will win Astros vs. Red Sox?

Using trusted machine learning and data, Dimers.com has simulated Wednesday's Astros-Red Sox MLB matchup 10,000 times.

Dimers' famous predictive analytics model, DimersBOT, currently gives the Astros a 54% chance of winning against the Red Sox .

More: Astros vs. Red Sox Simulated 10,000 Times

Astros vs. Red Sox Current Odds

• Run Line: Red Sox +1.5 (-140), Astros -1.5 (+126)
• Moneyline: Red Sox +114, Astros -130
• Total: Over/Under 9 (+105/-115)

Run Line, Moneyline and Over/Under

The Red Sox are +1.5 underdogs versus the Astros, with -140 at PointsBet the best odds currently available.

For the favored Astros (-1.5) to cover the run line, FanDuel Sportsbook has the best odds currently on offer at +126.

FanDuel Sportsbook currently has the best moneyline odds for the Red Sox at +114, which means you can bet $100 to profit $114, earning a total payout of $214, if they win.

Meanwhile, Caesars Sportsbook currently has the best moneyline odds for the Astros at -130, where you can risk $130 to win $100, for a total payout of $230, if they come out on top.

The Over/Under for total runs scored is set at 9 with Caesars Sportsbook, which currently has the best odds for the Over at +105, while DraftKings Sportsbook currently has the best odds for the Under at -115.

As always, check out the sportsbooks you have access to in your state for the best MLB odds and lines.

According to DimersBOT, the Red Sox (+1.5) are a 58% chance of covering the run line, while the 9-run Over/Under is a 51% chance of going Over.

More: Best Prop Bets Today

Best Bets for Astros vs. Red Sox

• Run Line: Red Sox +1.5 @ -140 via PointsBet (58% probability)
• Moneyline: Red Sox @ +114 via FanDuel Sportsbook
• Total: Over 9 @ +105 via Caesars Sportsbook (51% probability)

Dimers' best bets are based on complex simulations and wagering intelligence to help you make smarter decisions with the legal sportsbooks in your state.

While the Astros are more likely to win the game, according to DimersBOT, betting on the Red Sox moneyline is the best option due to the edge found when comparing our data-led probabilities to the sportsbooks' odds currently on offer.

Taking advantage of the edges published on Dimers.com is one of the keys to being a profitable sports bettor in the long run.

Astros vs. Red Sox Probabilities

Use our dynamic widget below to view the latest Moneyline, Over/Under and Run Line probabilities and odds for Houston vs. Boston, and click or tap on See Matchup to reveal more.

Dimers has full coverage of Wednesday's Astros-Red Sox matchup, including pregame predictions, free picks, and live win probabilities.

Don't forget, DimersBOT updates often, so keep an eye on this article for the latest betting insights ahead of Astros vs. Red Sox on Wednesday May 18, 2022.

Risk-Free Bet for Astros vs. Red Sox

Do you want the best sportsbook offer in America for Houston vs. Boston? Join FanDuel Sportsbook now and get your first bet risk free up to $1,000, which you can use on Wednesday's Astros-Red Sox matchup.

All you need to do is click or tap on this exclusive FanDuel Sportsbook link and create a new account – it's easy and takes less than 2 minutes.

Then, make your first deposit and place a bet up to $1,000 on Astros vs. Red Sox. If your bet doesn't win, FanDuel Sportsbook will give it back to you in site credit!

This offer is available to all new FanDuel Sportsbook users – no promo code needed!

Note: when you click or tap on a link on Dimers that leads to a third-party website that we have a commercial arrangement with (such as a sportsbook), we may earn a referral fee.

Astros vs. Red Sox 2022 Game Info

Wednesday's action between the Red Sox and Astros at Fenway Park is scheduled to start at 6:10PM ET.

• Date: Wednesday May 18, 2022
• Time: 6:10PM ET / 3:10PM PT
• Venue: Fenway Park

Looking to join an online sportsbook and start betting on MLB? We've reviewed the best available sign-up offers for every legal betting state.

What other MLB games are on today?

Now you've got the 411 on Astros vs. Red Sox, get the latest betting predictions for all upcoming MLB games in our MLB Bet Hub. There you can find probabilities and odds, plus our best bets for each and every MLB matchup.

Want a pick for the Run Line? You got it. How about the Over/Under? Yup, got that too. The Moneyline? Yes sir. And these picks are good, I mean REALLY good. Take a look now!

Finally, Dimers' MLB Futures page is our in-house approach to revealing who will win the 2022 World Series, with our data-led probabilities paired with the best odds available.