NFL picks straight up: Week 1, 2026

At Dimers, our Week 1 NFL picks are grounded in data-driven insight, with straight-up picks for all 16 games informed by our latest NFL predictions.

Gain the edge in your NFL pick 'em contests via our data-driven NFL Week 1 picks straight up, powered by thousands of game simulations.

Week 1 of the NFL season begins with the New England Patriots facing the Seattle Seahawks on Wednesday night and wraps up with the Denver Broncos taking on the Kansas City Chiefs on Monday night.

NFL picks this week straight up: Week 1, 2026

Here are our Week 1 NFL picks highlighting how likely each team is to win their game this week.

New England Patriots vs. Seattle Seahawks

The Patriots kick off Week 1 against the Seahawks at Lumen Field on Wednesday night. According to our predictive analytics model, the Seahawks have a 62% chance of winning, while the Patriots have a 38% chance.

For Week 1's opening game, our model highlights NFL player projections, with Rhamondre Stevenson (RB) the most likely player from the Patriots to score the first TD at 8.6%, while Jaxon Smith-Njigba (WR) is the top candidate from the Seahawks at 9.8%.

Check out our full New England Patriots vs. Seattle Seahawks prediction ahead of this week's matchup at Lumen Field, set for Wednesday, September 9 at 8:20pm. All times mentioned in this article are in Eastern Standard Time (EST).

San Francisco 49ers vs. Los Angeles Rams

For this week's game between the 49ers and the Rams, LA Rams is more likely to win. Our prediction model gives the Rams a 63% chance of winning. On the other hand, there is a 37% chance that the 49ers will pull off an upset win.

Explore the latest data in this week's San Francisco 49ers vs. Los Angeles Rams prediction before kickoff in Los Angeleson Thursday at 8:35pm.

As the season begins, track the top teams with our updated NFL futures, highlighting top Super Bowl contenders.

Chicago Bears vs. Carolina Panthers

We are picking the Bears to win their game against the Panthers this week, with our famous NFL model projecting a 60% win probability for the road team. The Panthers have a 40% chance of winning.

For betting purposes, the Panthers are listed as +3 underdogs, with the Bears' moneyline at -155.

Find the complete Chicago Bears vs. Carolina Panthers prediction for a closer look at Sunday's 1:00pm game.

Baltimore Ravens vs. Indianapolis Colts

According to our predictive analytics model, the Ravens are the team to beat in this game, with their win probability at 61%. The Colts, on the other hand, have a 39% chance of winning.

Review the edges and numbers in our Baltimore Ravens vs. Indianapolis Colts prediction for this Sunday 1:00pm clash at Lucas Oil Stadium.

Atlanta Falcons vs. Pittsburgh Steelers

The Steelers have a 62% chance of winning on Sunday afternoon, compared to the Falcons' 38% chance of victory. This makes the Pittsburgh Steelers our pick to win at Acrisure Stadium.

See the numbers behind this matchup in the full Atlanta Falcons vs. Pittsburgh Steelers prediction scheduled for Sunday at 1:00pm at Acrisure Stadium.

Cleveland Browns vs. Jacksonville Jaguars

The Jaguars are favored to win this one, with our model giving them a 78% chance, while the Browns enter the weekend with a 22% chance of causing an upset at EverBank Stadium.

When it comes to betting on this game, the Browns' moneyline odds are set at +350, with the home team Jaguars listed as -8.5 favorites.

This week's Cleveland Browns vs. Jacksonville Jaguars prediction highlights the top values for the game at EverBank Stadium on Sunday, September 13 at 1:00pm.

Tampa Bay Buccaneers vs. Cincinnati Bengals

After 10,000 simulations of Buccaneers vs. Bengals this Sunday, our model projects the Bengals as the more likely winners with a probability of 66%. Their opponents, the Buccaneers, have a 34% chance of getting the win on the road.

Compare projections and odds for this matchup in our Tampa Bay Buccaneers vs. Cincinnati Bengals prediction, set for Sunday at 1:00pm.

New York Jets vs. Tennessee Titans

Our model is picking the Titans, who have a 54% chance of winning the game, while the Jets have a 46% win probability.

Access the full data breakdown in our New York Jets vs. Tennessee Titans prediction ahead of kickoff at Nissan Stadium.

New Orleans Saints vs. Detroit Lions

The next game of Week 1 sees the Saints take on the Lions at Ford Field.

We predict the Lions to win with a probability of 72%, while the Saints are projected to have a win chance of 28%.

As for the Vegas betting odds here, the Lions are listed as -7 favorites, with the Saints' moneyline odds posted at +275.

Breakdown further probabilities and player projections in the New Orleans Saints vs. Detroit Lions prediction for Sunday, September 13 at 1:00pm.

Buffalo Bills vs. Houston Texans

The likely winner of this matchup is the Bills, who have a projected win chance of 58%, according to DimersBOT. On the other side of this matchup, the Texans have a projected win probability of 42%.

Check out our Buffalo Bills vs. Houston Texans prediction to see where the rest of the numbers lean ahead of Sunday's game in Houston.

Arizona Cardinals vs. Los Angeles Chargers

We have run our powerful NFL model over this week’s Cardinals-Chargers clash 10,000 times, with the Chargers coming out as the team to pick. Of those 10,000 simulations, the Chargers won 7,728 times, with the Cardinals winning on 2,272 occasions.

Get direct access to more game projections with our Arizona Cardinals vs. Los Angeles Chargers prediction before Sunday's clash at SoFi Stadium

Green Bay Packers vs. Minnesota Vikings

Next up is the game between the Packers and Vikings, with our model projecting the home team as the more likely victor, with the Vikings rated as having a 55% chance of getting the W. The Packers, on the other hand, are projected to have a 45% chance of winning.

For those interested in betting on this matchup, the oddsmakers have the Packers' moneyline odds set at +102 for this road game, while the hosting Vikings are listed as -1.5 favorites.

Examine further probabilities in the full Green Bay Packers vs. Minnesota Vikings prediction, scheduled for Sunday at 4:25pm.

Miami Dolphins vs. Las Vegas Raiders

Our next straight up pick this week is for the Raiders to get the win against the Dolphins. After running 10,000 simulations of this matchup, the Las Vegas have a win probability of 60%, with the Dolphins at 40%.

View the complete Miami Dolphins vs. Las Vegas Raiders prediction for a deeper look at this Sunday's game in Las Vegas.

Washington Commanders vs. Philadelphia Eagles

With a win probability of 67% on Sunday afternoon, our straight up pick for this matchup is the Eagles, while their opponent, the Commanders, have a projected win chance of 33%.

Check out the latest projections in this week's Washington Commanders vs. Philadelphia Eagles prediction before kickoff on Sunday, September 13 at 4:25pm.

Dallas Cowboys vs. New York Giants

The team to pick here is the Cowboys, who have a 61% chance of winning their matchup against the Giants this Sunday night.

Looking at the betting odds for this Sunday Night Football clash, the Giants are listed as +2.5 underdogs at home, with the Cowboys' moneyline odds available at -152.

Find all game probabilities and odds in the full Dallas Cowboys vs. New York Giants prediction for Sunday's matchup at MetLife Stadium.

Denver Broncos vs. Kansas City Chiefs

Our pick to win the final game of Week 1 is the Chiefs, who have a win probability of 59%. Their opponents are projected to have a 41% chance of getting the W.

See where the projections identify value in our Denver Broncos vs. Kansas City Chiefs prediction, set for Monday at 8:15pm at Arrowhead Stadium.

Full list of NFL Week 1 picks straight up

• Seahawks (62% win probability)
• Rams (63%)
• Bears (60%)
• Ravens (61%)
• Steelers (62%)
• Jaguars (78%)
• Bengals (66%)
• Titans (54%)
• Lions (72%)
• Bills (58%)
• Chargers (77%)
• Vikings (55%)
• Raiders (60%)
• Eagles (67%)
• Cowboys (61%)
• Chiefs (59%)

NFL straight up picks and predictions for Week 1

The NFL Week 1 predictions straight up in this article are accurate at the time of publication but may change.

Dimers.com is the best site for NFL predictions, with our straight up picks trusted by football fans across the country.

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Please note that all NFL odds and probabilities mentioned on this page are subject to change.