Cardinals vs. Chargers: NFL Week 1 Prediction, Picks & Odds
- Cardinals
- Chargers
| TEAM | 1 | 2 | 3 | 4 | T |
|---|---|---|---|---|---|
Cardinals | 7 | 6 | 3 | 10 | 26 |
Chargers | 7 | 0 | 7 | 0 | 14 |
Cardinals vs. Chargers: Detailed Breakdown
Matchup overview: NFL Week 1
- Teams: Arizona Cardinals vs. Los Angeles Chargers
- Date: Sunday, September 13, 2026
- Time: 4:25PM ET
- Venue: SoFi Stadium
Current betting odds
- Spread: Cardinals (+8.5, +100), Chargers (-8.5, -102)
- Moneyline: Cardinals +426, Chargers -441
- Total (Over/Under): 46.5 points (-108/+104)
Dimers’ win probabilities
- Cardinals: 22.7%
- Chargers: 77.3%
These probabilities come from two machine learning models that assess more than 100 data points for each NFL matchup, combining their outputs to project all our major betting markets.
Projected final score
Our predicted final score for this NFL matchup is Cardinals 18-27 Chargers.
This prediction draws on each team's scoring trends and player stats, weighed across both of our data models.
Our Prediction: Who Wins?
The numbers give the Cardinals a win probability of 22.7%, while the Chargers have a win probability of 77.3%.
Summary
The Cardinals face off against the Chargers in the NFL at SoFi Stadium on Sunday, September 13, 2026.
Our Cardinals vs. Chargers predictions, built on real-time data and matchup-specific modeling, help guide your decisions.. Remember to bet responsibly and within your financial limits.
For additional resources and advice on responsible gambling please call 1-800-GAMBLER.
When you click or tap on a link on Dimers that goes to a third-party website that we have a commercial relationship with (such as a sportsbook), we may receive a referral fee.
For further insights, explore our expert NFL predictions and the best NFL bets today, while our in-depth analysis includes NFL props, NFL futures, NFL odds, and the latest NFL news.