Yankees vs. Tigers Prediction and Odds - Apr 21, 2022

The Detroit Tigers and New York Yankees lock horns in MLB at Comerica Park on Thursday, starting at 1:10PM ET.

Michael Pineda (0-0, 0.00 ERA) will be on the bump for the Tigers, while the Yankees will counter with Jordan Montgomery (0-0, 3.24 ERA).

Dimers' best betting picks for Yankees vs. Tigers, as well as game predictions and best odds, are featured in this article.

Who will win Yankees vs. Tigers?

Based on trusted machine learning and data, Dimers.com has simulated Thursday's Yankees-Tigers MLB game 10,000 times.

Dimers' leading predictive analytics model, DimersBOT, currently gives the Yankees a 59% chance of winning against the Tigers.

More: Yankees vs. Tigers Simulated 10,000 Times

Yankees vs. Tigers Odds

• Run Line: Tigers +1.5 (-105), Yankees -1.5 (-105)
• Moneyline: Tigers +150, Yankees -165
• Total: Over/Under 8.5 (-110/-110)

Run Line, Moneyline and Over/Under

The Tigers are +1.5 underdogs versus the Yankees, with -105 at DraftKings Sportsbook the best odds currently available.

For the favored Yankees (-1.5) to cover the run line, BetMGM has the best odds currently on offer at -105.

Caesars Sportsbook currently has the best moneyline odds for the Tigers at +150, which means you can bet $100 to profit $150, earning a total payout of $250, if they win.

On the other hand, DraftKings Sportsbook currently has the best moneyline odds for the Yankees at -165, where you can risk $165 to win $100, for a total payout of $265, if they come out on top.

The Over/Under for total runs scored is set at 8.5 with Caesars Sportsbook, which currently has the best odds for the Over at -110, as well as the best odds for the Under at -110.

As always, make sure you check all the legal sportbooks available in your state for the best MLB odds and lines.

According to DimersBOT, the Tigers (+1.5) are a 53% chance of covering the run line, while the Over/Under total of 8.5 runs is a 51% chance of going Over.

More: Predictions for Every MLB Game

Best Bets for Yankees vs. Tigers

• Run Line: Tigers +1.5 @ -105 via DraftKings Sportsbook (53% probability)
• Moneyline: Tigers @ +150 via Caesars Sportsbook (0.8% edge)
• Total: Over 8.5 @ -110 via Caesars Sportsbook (51% probability)

Dimers' best bets are based on complex simulations and betting intelligence to bring you the best possible plays 24/7.

While the Yankees are more likely to win the game, according to DimersBOT, betting on the Tigers moneyline is the best option because of the edge identified when comparing our data-led probabilities to the sportsbooks' odds currently on offer.

Taking advantage of the edges published here at Dimers.com is pivotal to being a profitable sports bettor in the long run.

Yankees vs. Tigers Probabilities

Use our dynamic widget below to see the latest Moneyline, Over/Under and Run Line probabilities and odds for NY Yankees vs. Detroit, and click or tap on See Matchup for more.

Dimers has full betting coverage of Thursday's Yankees-Tigers matchup, including pregame predictions, best betting picks, and live win probabilities.

Don't forget, DimersBOT updates regularly, so refresh this page for any changes to our betting insights before Yankees vs. Tigers on Thursday April 21, 2022.

Best Betting Promo for Yankees vs. Tigers

Looking for the best sportsbook offer in America for NY Yankees vs. Detroit? Join FanDuel Sportsbook now and get a risk-free first bet up to $1,000, which you can use on Thursday's Yankees-Tigers matchup.

All you need to do is click or tap on this exclusive FanDuel Sportsbook link and create an account – it's easy and takes less than 2 minutes.

Then, make your first deposit and place a bet up to $1,000 on Yankees vs. Tigers. If you don't win your bet, FanDuel Sportsbook will give it back to you in site credit!

This promo is available to all new FanDuel Sportsbook users. How good is that!

Note: when you click or tap on a link on Dimers that leads to a third-party website that we have a commercial arrangement with (such as a sportsbook), we may earn a referral fee.

Yankees vs. Tigers 2022 Game Info

When do the Tigers play the Yankees?

• Date: Thursday April 21, 2022
• Time: 1:10PM ET / 10:10AM PT
• Venue: Comerica Park

Want to join an online sportsbook and start betting on MLB? Check out the best sportsbook sign-up offers in your state.

Want more MLB predictions like this?

So, you liked our Yankees vs. Tigers betting analysis? Awesome. Did you know our MLB Betting News page has a comprehensive betting preview for every MLB game the second the sportsbooks release their odds?

That's right, our predictive analytics model then compares those odds against its own probabilities to find value in the markets, which allows us to write the most accurate MLB betting previews and beat the public and the sportsbooks to the punch.

It's only a click away, so why not see for yourself?

Lastly, Dimers' MLB Futures page is our in-house approach to revealing who will win the 2022 World Series, with our data-led probabilities compared to the best odds to win the World Series.