White Sox vs. Red Sox Prediction and Odds - May 6, 2022

The Boston Red Sox take on the Chicago White Sox in MLB action at Fenway Park on Friday, starting at 7:10PM ET.

Nathan Eovaldi (1-0, 2.51 ERA) will start on the mound for the Red Sox, while the White Sox are going with Vince Velasquez (1-2, 4.58 ERA).

Dimers' top betting picks for White Sox vs. Red Sox, plus game predictions and best odds, are detailed below.

Today's CHI White Sox vs. Boston betting preview is sponsored by PointsBet, which has a great 5x $100 Risk-Free Bets promo for new customers.

Who will win White Sox vs. Red Sox?

Based on cutting-edge computer power and data, Dimers.com has simulated Friday's White Sox-Red Sox MLB game 10,000 times.

Dimers' famous predictive analytics model, DimersBOT, currently gives the Red Sox a 60% chance of getting the W against the White Sox.

More: Free Betting Analysis for White Sox vs. Red Sox

White Sox vs. Red Sox Game Odds

• Run Line: Red Sox -1.5 (+125), White Sox +1.5 (-135)
• Moneyline: Red Sox -164, White Sox +145
• Total: Over/Under 8.5 (+100/-115)

Run Line, Moneyline and Over/Under

The Red Sox are -1.5 favorites against the White Sox, with +125 at FanDuel Sportsbook the best odds currently available.

For the underdog White Sox (+1.5) to cover the run line, BetMGM has the best odds currently on the market at -135.

Caesars Sportsbook currently has the best moneyline odds for the Red Sox at -164, which means you can risk $164 to win $100, for a total payout of $264, if they get the W.

Meanwhile, BetMGM currently has the best moneyline odds for the White Sox at +145, where you can put down $100 to profit $145, earning a total payout of $245, if they win.

The Over/Under for total runs scored sits at 8.5 with DraftKings Sportsbook, which currently has the best odds for the Over at +100, while Caesars Sportsbook currently has the best odds for the Under at -115.

As always, check out all the online sportsbooks that are available in your state for the best MLB odds and lines.

According to DimersBOT, the White Sox (+1.5) are a 58% chance of covering the run line, while the Over/Under total of 8.5 runs is a 51% chance of going Over.

More: Best Bets for Every MLB Game

Best Bets for White Sox vs. Red Sox

• Run Line: White Sox +1.5 @ -135 via BetMGM (58% probability)
• Moneyline: White Sox @ +145 via BetMGM
• Total: Over 8.5 @ +100 via DraftKings Sportsbook (51% probability)

Dimers' best bets are based on complex simulations and wagering intelligence to serve you the best possible plays 24/7/365.

While the Red Sox are more likely to win the game, according to DimersBOT, betting on the White Sox moneyline is the best option because of the edge identified when comparing our data-led probabilities to the sportsbooks' odds currently on offer.

Taking advantage of the edges published on Dimers is pivotal to achieving long-term profitability.

White Sox vs. Red Sox Betting Guide

Use our interactive widget below to explore the latest Moneyline, Over/Under and Run Line probabilities and odds for CHI White Sox vs. Boston, and click or tap on See Matchup for more.

Dimers has full coverage of Friday's White Sox-Red Sox matchup, including pregame predictions, computer picks, and live win probabilities.

Remember, DimersBOT updates frequently, so keep checking this page for any changes to our betting analysis before White Sox vs. Red Sox on Friday May 6, 2022.

Claim Your Risk-Free Bet for White Sox vs. Red Sox

Do you want the best sportsbook offer in America for CHI White Sox vs. Boston? Join FanDuel Sportsbook today and get a risk-free first bet up to $1,000, which you can use on Friday's White Sox-Red Sox game.

Simply click or tap on this exclusive FanDuel Sportsbook link and create an account – it's easy and takes less than 2 minutes.

Then, make your first deposit and place a bet up to $1,000 on White Sox vs. Red Sox. If you don't win your bet, FanDuel Sportsbook will refund it in site credit!

This promo is available to all new FanDuel Sportsbook users. How good is that!

Note: when you click or tap on a link on Dimers that leads to a third-party website that we have a commercial arrangement with (such as a sportsbook), we may earn a referral fee.

White Sox vs. Red Sox 2022 Game Info

When do the Red Sox play the White Sox?

• Date: Friday May 6, 2022
• Time: 7:10PM ET / 4:10PM PT
• Venue: Fenway Park

Enjoy Dimers.com and want to keep the site free? Every time you sign up and bet with a sportsbook featured here, we get paid a small fee.

These fees help us keep Dimers free for all sports fans. So, if you like what you see, support us by joining one of our trusted sports betting partners now.

What other MLB games are on today?

Now you've got the 411 on White Sox vs. Red Sox, see the latest betting predictions for all upcoming MLB games in our MLB Bet Hub. There you can find probabilities and odds, plus our best bets for each and every MLB matchup.

Want a pick for the Run Line? You got it. How about the Over/Under? Yup, got that too. The Moneyline? Yes sir. And these picks are good, I mean REALLY good. Take a look now!

While you're here, Dimers' Baseball Futures page is our in-house approach to determining who will win the 2022 World Series, with our data-led probabilities matched against the best odds to win the World Series.