White Sox vs. Guardians Prediction and Odds - Apr 21, 2022

The Cleveland Guardians take on the Chicago White Sox in MLB action at Progressive Field on Thursday, commencing at 1:10PM ET.

Zach Plesac (0-1, 1.64 ERA) will start for the Guardians, pitting him against Dylan Cease (2-0, 1.69 ERA) for the White Sox.

Dimers' free betting picks for White Sox vs. Guardians, plus game predictions and best odds, are featured in this article.

Who will win White Sox vs. Guardians?

Based on trusted machine learning and data, Dimers.com has simulated Thursday's White Sox-Guardians MLB matchup 10,000 times.

Dimers' leading predictive analytics model, DimersBOT, currently gives the White Sox a 55% chance of defeating the Guardians.

More: White Sox vs. Guardians Simulated 10,000 Times

White Sox vs. Guardians Current Odds

• Run Line: Guardians +1.5 (-130), White Sox -1.5 (+114)
• Moneyline: Guardians +130, White Sox -145
• Total: Over/Under 7.5 (-120/+100)

Run Line, Moneyline and Over/Under

The Guardians are +1.5 underdogs against the White Sox, with -130 at Caesars Sportsbook the best odds currently available.

For the favored White Sox (-1.5) to cover the run line, FanDuel Sportsbook has the best odds currently on offer at +114.

PointsBet currently has the best moneyline odds for the Guardians at +130, which means you can throw down $100 to profit $130, earning a total payout of $230, if they win.

Meanwhile, DraftKings Sportsbook currently has the best moneyline odds for the White Sox at -145, where you can risk $145 to win $100, for a total payout of $245, if they come out on top.

The Over/Under sits at 7.5 with DraftKings Sportsbook, which currently has the best odds for the Over at -120, as well as the best odds for the Under at +100.

As always, make sure you check all the online sportsbooks that are available in your state for the best MLB odds and lines.

According to DimersBOT, the Guardians (+1.5) are a 58% chance of covering the run line, while the Over/Under total of 7.5 runs is a 57% chance of going Over.

More: Live Scores for All Major Sports

Best Bets for White Sox vs. Guardians

• Run Line: Guardians +1.5 @ -130 via Caesars Sportsbook (58% probability)
• Moneyline: Guardians @ +130 via PointsBet (1.8% edge)
• Total: Over 7.5 @ -120 via DraftKings Sportsbook (57% probability)

Dimers' best bets are based on detailed simulations and wagering intelligence to serve you the best possible plays every day of the year.

While the White Sox are more likely to win the game, according to DimersBOT, taking the Guardians moneyline is the best option due to the 1.8% edge found when comparing our data-led probabilities to the betting odds currently available.

Taking advantage of the edges published on Dimers is one of the keys to being a profitable bettor in the long run.

White Sox vs. Guardians Betting Guide

Use our interactive widget below to view the latest Moneyline, Over/Under and Run Line probabilities and odds for CHI White Sox vs. Cleveland, and click or tap on See Matchup for more.

Dimers has full coverage of Thursday's White Sox-Guardians matchup, including pregame predictions, top betting picks, and live win probabilities.

Remember, DimersBOT updates regularly, so keep checking this page for any changes to our betting insights ahead of White Sox vs. Guardians on Thursday April 21, 2022.

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Note: when you click or tap on a link on Dimers that leads to a third-party website that we have a commercial arrangement with (such as a sportsbook), we may earn a referral fee.

White Sox vs. Guardians 2022 Game Info

When do the Guardians play the White Sox?

• Date: Thursday April 21, 2022
• Time: 1:10PM ET / 10:10AM PT
• Venue: Progressive Field

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Want more MLB analysis like this?

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We use the power of predictive analytics to find value in the markets so we can publish the most comprehensive MLB betting previews available. We do this by comparing our in-house probabilities against the sportsbooks' odds (aka Vegas odds) the minute they go live.

So, get ahead of the game and beat the 'books today – it's only a click away.

While you're here, Dimers' Baseball Futures page is our in-house approach to revealing who will win the 2022 World Series, with our data-led probabilities matched against the best odds to win the World Series.