White Sox vs. Guardians Prediction and Odds - Apr 20, 2022

The Cleveland Guardians take on the Chicago White Sox in MLB action at Progressive Field on Wednesday, starting at 6:10PM EDT.

Triston McKenzie (0-1, 2.57 ERA) will be on the bump for the Guardians, while the White Sox will counter with Jimmy Lambert (0-1, 6.00 ERA).

Dimers' top betting picks for White Sox vs. Guardians, as well as game predictions and best odds, are featured below.

Who will win White Sox vs. Guardians?

Using state-of-the-art computer power and data, Dimers.com has simulated Wednesday's White Sox-Guardians MLB game 10,000 times.

Dimers' revolutionary predictive analytics model, DimersBOT, currently gives the Guardians a 57% chance of defeating the White Sox.

More: White Sox vs. Guardians Simulated 10K Times

White Sox vs. Guardians Current Odds

• Run Line: Guardians -1.5 (+165), White Sox +1.5 (-149)
• Moneyline: Guardians -130, White Sox +130
• Total: Over/Under 7.5 (-110/-110)

Run Line, Moneyline and Over/Under

The Guardians are -1.5 favorites against the White Sox, with +165 at PointsBet the best odds currently available.

For the underdog White Sox (+1.5) to cover the run line, Caesars Sportsbook has the best odds currently on the market at -149.

DraftKings Sportsbook currently has the best moneyline odds for the Guardians at -130. That means you can risk $130 to win $100, for a total payout of $230, if they get the W.

On the other hand, Caesars Sportsbook currently has the best moneyline odds for the White Sox at +130, where you can bet $100 to profit $130, earning a total payout of $230, if they win.

The Over/Under is set at 7.5 with Caesars Sportsbook, which currently has the best odds for the Over at -110, as well as the best odds for the Under at -110.

As always, check out all the legal sportbooks available in your state for the best MLB odds and lines.

According to DimersBOT, the White Sox (+1.5) are a 62% chance of covering the run line, while the Over/Under total of 7.5 runs is a 55% chance of going Over.

More: Live Win Probabilities for All Major Sports

Best Bets for White Sox vs. Guardians

• Run Line: White Sox +1.5 @ -149 via Caesars Sportsbook (62% probability)
• Moneyline: Guardians @ -130 via DraftKings Sportsbook (57% probability)
• Total: Over 7.5 @ -110 via Caesars Sportsbook (55% probability)

Dimers' best bets are based on complex simulations and betting intelligence to help you make more informed decisions with the legal sportsbooks in the United States.

White Sox vs. Guardians Probabilities

Use our dynamic widget below to view up-to-date Moneyline, Over/Under and Run Line probabilities and odds for CHI White Sox vs. Cleveland, and click or tap on See Matchup for more.

Dimers has full coverage of Wednesday's White Sox-Guardians matchup, including pre-game predictions, free betting picks, and live win probabilities.

Remember, DimersBOT updates often, so keep an eye on this article for the latest betting analysis before White Sox vs. Guardians on Wednesday April 20, 2022.

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White Sox vs. Guardians 2022 Game Info

When do the Guardians play the White Sox?

• Date: Wednesday April 20, 2022
• Time: 6:10PM EDT / 3:10PM PDT
• Venue: Progressive Field

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What MLB games are on today?

The White Sox and Guardians aren't the only two MLB teams you can bet on today. DimersBOT never stops and we've got picks and best bets for every single MLB game in our MLB Bet Hub page.

Not only do we provide with you great predictions, but we also have recommended bets for the Run Line, Over/Under and Moneyline. Sound good? Check it out today!

Finally, Dimers' MLB Futures page is our in-house approach to determining who will win the 2022 World Series, with our data-led probabilities paired with the best odds on the market.